Epigenome dysregulation in cholangiocarcinoma

Colm J O'Rourke; Patricia Munoz-Garrido; Esmeralda L Aguayo; Jesper B Andersen

doi:10.1016/j.bbadis.2017.06.014

Epigenome dysregulation in cholangiocarcinoma

Colm J O'Rourke, Patricia Munoz-Garrido, Esmeralda L Aguayo, Jesper B Andersen

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Abstract

Epigenomics is a fast-evolving field of research that has lately attracted considerable interest, mainly due to the reversibility of epigenetic marks. Clinically, among solid tumors, the field is still limited. In cholangiocarcinoma (CCA) it is well known that the epigenetic landscape is deregulated both during carcinogenesis and disease progression as a consequence of aberrant mechanisms leading to genome instability. In this article, we will briefly review the molecular alterations that have been described in the transformation of normal cholangiocytes into malignant derivatives, focusing on the role of non-coding RNA (ncRNA) interactions, DNA methylation, post-translational modifications (PTMs) of histones and chromatin remodeling complexes.

Original language	English
Journal	BBA Molecular Basis of Disease
Volume	1864
Issue number	4, Part B
Pages (from-to)	1423-1434
Number of pages	12
ISSN	0925-4439
DOIs	https://doi.org/10.1016/j.bbadis.2017.06.014
Publication status	Published - Apr 2018

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10.1016/j.bbadis.2017.06.014

EPIGENOME DYSREGULATION IN CHOLANGIOCARCINOMAAccepted author manuscript, 4.45 MBLicence: Unspecified

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title = "Epigenome dysregulation in cholangiocarcinoma",

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AU - O'Rourke, Colm J

AU - Munoz-Garrido, Patricia

AU - Aguayo, Esmeralda L

AU - Andersen, Jesper B

PY - 2018/4

Y1 - 2018/4

N2 - Epigenomics is a fast-evolving field of research that has lately attracted considerable interest, mainly due to the reversibility of epigenetic marks. Clinically, among solid tumors, the field is still limited. In cholangiocarcinoma (CCA) it is well known that the epigenetic landscape is deregulated both during carcinogenesis and disease progression as a consequence of aberrant mechanisms leading to genome instability. In this article, we will briefly review the molecular alterations that have been described in the transformation of normal cholangiocytes into malignant derivatives, focusing on the role of non-coding RNA (ncRNA) interactions, DNA methylation, post-translational modifications (PTMs) of histones and chromatin remodeling complexes.

AB - Epigenomics is a fast-evolving field of research that has lately attracted considerable interest, mainly due to the reversibility of epigenetic marks. Clinically, among solid tumors, the field is still limited. In cholangiocarcinoma (CCA) it is well known that the epigenetic landscape is deregulated both during carcinogenesis and disease progression as a consequence of aberrant mechanisms leading to genome instability. In this article, we will briefly review the molecular alterations that have been described in the transformation of normal cholangiocytes into malignant derivatives, focusing on the role of non-coding RNA (ncRNA) interactions, DNA methylation, post-translational modifications (PTMs) of histones and chromatin remodeling complexes.

KW - Journal Article

KW - Review

U2 - 10.1016/j.bbadis.2017.06.014

DO - 10.1016/j.bbadis.2017.06.014

M3 - Review

C2 - 28645654

SN - 0925-4439

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EP - 1434

JO - BBA Molecular Basis of Disease

JF - BBA Molecular Basis of Disease

IS - 4, Part B

ER -

Epigenome dysregulation in cholangiocarcinoma

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