Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave

Muhammad Shoaib; Claus Storgaard Sørensen

doi:10.1016/j.ccell.2015.10.009

Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave

Muhammad Shoaib, Claus Storgaard Sørensen

5 Citations (Scopus)

Abstract

Cancer cell-specific synthetic lethal interactions entail promising therapeutic possibilities. In this issue of Cancer Cell, Pfister et al. describe a synthetic lethal interaction where cancer cells deficient in H3K36me3 owing to SETD2 loss-of-function mutation are strongly sensitized to inhibition of WEE1, a cell cycle controlling kinase.

Original language	English
Journal	Cancer Cell
Volume	28
Issue number	5
Pages (from-to)	545-547
Number of pages	3
ISSN	1535-6108
DOIs	https://doi.org/10.1016/j.ccell.2015.10.009
Publication status	Published - 9 Nov 2015

Keywords

Animals
Cell Cycle Proteins
Histones
Humans
Neoplasms
Nuclear Proteins
Nucleotides
Protein-Tyrosine Kinases
Comment
Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ccell.2015.10.009

http://www.cell.com/article/S1535610815003864/pdf

Cite this

@article{0a8a6ec331a14fb7ac3933083a1d1bcb,

title = "Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave",

abstract = "Cancer cell-specific synthetic lethal interactions entail promising therapeutic possibilities. In this issue of Cancer Cell, Pfister et al. describe a synthetic lethal interaction where cancer cells deficient in H3K36me3 owing to SETD2 loss-of-function mutation are strongly sensitized to inhibition of WEE1, a cell cycle controlling kinase.",

keywords = "Animals, Cell Cycle Proteins, Histones, Humans, Neoplasms, Nuclear Proteins, Nucleotides, Protein-Tyrosine Kinases, Comment, Journal Article",

author = "Muhammad Shoaib and S{\o}rensen, {Claus Storgaard}",

year = "2015",

month = nov,

day = "9",

doi = "10.1016/j.ccell.2015.10.009",

language = "English",

volume = "28",

pages = "545--547",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "5",

}

TY - JOUR

T1 - Epigenetic Deficiencies and Replicative Stress

T2 - Driving Cancer Cells to an Early Grave

AU - Shoaib, Muhammad

AU - Sørensen, Claus Storgaard

PY - 2015/11/9

Y1 - 2015/11/9

N2 - Cancer cell-specific synthetic lethal interactions entail promising therapeutic possibilities. In this issue of Cancer Cell, Pfister et al. describe a synthetic lethal interaction where cancer cells deficient in H3K36me3 owing to SETD2 loss-of-function mutation are strongly sensitized to inhibition of WEE1, a cell cycle controlling kinase.

AB - Cancer cell-specific synthetic lethal interactions entail promising therapeutic possibilities. In this issue of Cancer Cell, Pfister et al. describe a synthetic lethal interaction where cancer cells deficient in H3K36me3 owing to SETD2 loss-of-function mutation are strongly sensitized to inhibition of WEE1, a cell cycle controlling kinase.

KW - Animals

KW - Cell Cycle Proteins

KW - Histones

KW - Humans

KW - Neoplasms

KW - Nuclear Proteins

KW - Nucleotides

KW - Protein-Tyrosine Kinases

KW - Comment

KW - Journal Article

U2 - 10.1016/j.ccell.2015.10.009

DO - 10.1016/j.ccell.2015.10.009

M3 - Journal article

C2 - 26555168

SN - 1535-6108

VL - 28

SP - 545

EP - 547

JO - Cancer Cell

JF - Cancer Cell

IS - 5

ER -

Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this