Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave

Muhammad Shoaib; Claus Storgaard Sørensen

doi:10.1016/j.ccell.2015.10.009

Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave

Muhammad Shoaib, Claus Storgaard Sørensen

5 Citationer (Scopus)

Abstract

Cancer cell-specific synthetic lethal interactions entail promising therapeutic possibilities. In this issue of Cancer Cell, Pfister et al. describe a synthetic lethal interaction where cancer cells deficient in H3K36me3 owing to SETD2 loss-of-function mutation are strongly sensitized to inhibition of WEE1, a cell cycle controlling kinase.

Originalsprog	Engelsk
Tidsskrift	Cancer Cell
Vol/bind	28
Udgave nummer	5
Sider (fra-til)	545-547
Antal sider	3
ISSN	1535-6108
DOI	https://doi.org/10.1016/j.ccell.2015.10.009
Status	Udgivet - 9 nov. 2015

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10.1016/j.ccell.2015.10.009

http://www.cell.com/article/S1535610815003864/pdf

Citationsformater

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abstract = "Cancer cell-specific synthetic lethal interactions entail promising therapeutic possibilities. In this issue of Cancer Cell, Pfister et al. describe a synthetic lethal interaction where cancer cells deficient in H3K36me3 owing to SETD2 loss-of-function mutation are strongly sensitized to inhibition of WEE1, a cell cycle controlling kinase.",

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AU - Sørensen, Claus Storgaard

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AB - Cancer cell-specific synthetic lethal interactions entail promising therapeutic possibilities. In this issue of Cancer Cell, Pfister et al. describe a synthetic lethal interaction where cancer cells deficient in H3K36me3 owing to SETD2 loss-of-function mutation are strongly sensitized to inhibition of WEE1, a cell cycle controlling kinase.

KW - Animals

KW - Cell Cycle Proteins

KW - Histones

KW - Humans

KW - Neoplasms

KW - Nuclear Proteins

KW - Nucleotides

KW - Protein-Tyrosine Kinases

KW - Comment

KW - Journal Article

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DO - 10.1016/j.ccell.2015.10.009

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Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave

Abstract

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