Epidemiology of helminth infections and their relationship to clinical malaria in southwest Uganda

Adrienne E. Shapiro; Edridah M. Tukahebwa; Jennifer Kasten; Siân E. Clarke; Pascal Magnussen; Annette Olsen; Narcis B. Kabatereine; Richard Ndyomugyenyi; Simon Brooker

doi:10.1016/j.trstmh.2004.02.006

Epidemiology of helminth infections and their relationship to clinical malaria in southwest Uganda

Adrienne E. Shapiro, Edridah M. Tukahebwa, Jennifer Kasten, Siân E. Clarke, Pascal Magnussen, Annette Olsen, Narcis B. Kabatereine, Richard Ndyomugyenyi, Simon Brooker^*

^*Corresponding author for this work

DRUGS team

89 Citations (Scopus)

Abstract

It has recently been suggested that helminth infections may adversely influence susceptibility to other infections, including malaria. To investigate this hypothesis in a sub-Saharan African setting, surveys of helminth infections were conducted in 2003 among individuals who had been under weekly active case detection for clinical malaria during the preceding 18 months in four villages in Kabale District, southwest Uganda. Overall, 47.3% of individuals had at least one intestinal nematode species infection: hookworm, Ascaris lumbricoides and Trichuris trichiura were detected in 32.1, 17.4 and 8.1% of individuals, respectively. We found evidence of significant household clustering of A. lumbricoides, T. trichiura and hookworm, and clustering of heavy infection of each species. The association between helminth infection and clinical malaria was investigated in two villages and no evidence for an association was observed between the presence of infection or heavy infection and risk of malaria.

Original language	English
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	99
Issue number	1
Pages (from-to)	18-24
Number of pages	7
ISSN	0035-9203
DOIs	https://doi.org/10.1016/j.trstmh.2004.02.006
Publication status	Published - 1 Jan 2005

Keywords

Ascaris lumbricoides
Helminths
Hookworm
Malaria
Trichuris trichiura
Uganda

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.trstmh.2004.02.006

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Shapiro, A. E., Tukahebwa, E. M., Kasten, J., Clarke, S. E., Magnussen, P., Olsen, A., Kabatereine, N. B., Ndyomugyenyi, R., & Brooker, S. (2005). Epidemiology of helminth infections and their relationship to clinical malaria in southwest Uganda. Transactions of the Royal Society of Tropical Medicine and Hygiene, 99(1), 18-24. https://doi.org/10.1016/j.trstmh.2004.02.006

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AU - Tukahebwa, Edridah M.

AU - Kasten, Jennifer

AU - Clarke, Siân E.

AU - Magnussen, Pascal

AU - Olsen, Annette

AU - Kabatereine, Narcis B.

AU - Ndyomugyenyi, Richard

AU - Brooker, Simon

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N2 - It has recently been suggested that helminth infections may adversely influence susceptibility to other infections, including malaria. To investigate this hypothesis in a sub-Saharan African setting, surveys of helminth infections were conducted in 2003 among individuals who had been under weekly active case detection for clinical malaria during the preceding 18 months in four villages in Kabale District, southwest Uganda. Overall, 47.3% of individuals had at least one intestinal nematode species infection: hookworm, Ascaris lumbricoides and Trichuris trichiura were detected in 32.1, 17.4 and 8.1% of individuals, respectively. We found evidence of significant household clustering of A. lumbricoides, T. trichiura and hookworm, and clustering of heavy infection of each species. The association between helminth infection and clinical malaria was investigated in two villages and no evidence for an association was observed between the presence of infection or heavy infection and risk of malaria.

AB - It has recently been suggested that helminth infections may adversely influence susceptibility to other infections, including malaria. To investigate this hypothesis in a sub-Saharan African setting, surveys of helminth infections were conducted in 2003 among individuals who had been under weekly active case detection for clinical malaria during the preceding 18 months in four villages in Kabale District, southwest Uganda. Overall, 47.3% of individuals had at least one intestinal nematode species infection: hookworm, Ascaris lumbricoides and Trichuris trichiura were detected in 32.1, 17.4 and 8.1% of individuals, respectively. We found evidence of significant household clustering of A. lumbricoides, T. trichiura and hookworm, and clustering of heavy infection of each species. The association between helminth infection and clinical malaria was investigated in two villages and no evidence for an association was observed between the presence of infection or heavy infection and risk of malaria.

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KW - Hookworm

KW - Malaria

KW - Trichuris trichiura

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Epidemiology of helminth infections and their relationship to clinical malaria in southwest Uganda

Abstract

Keywords

UN SDGs

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