TY - JOUR
T1 - Epidemiology of helminth infections and their relationship to clinical malaria in southwest Uganda
AU - Shapiro, Adrienne E.
AU - Tukahebwa, Edridah M.
AU - Kasten, Jennifer
AU - Clarke, Siân E.
AU - Magnussen, Pascal
AU - Olsen, Annette
AU - Kabatereine, Narcis B.
AU - Ndyomugyenyi, Richard
AU - Brooker, Simon
PY - 2005/1/1
Y1 - 2005/1/1
N2 - It has recently been suggested that helminth infections may adversely influence susceptibility to other infections, including malaria. To investigate this hypothesis in a sub-Saharan African setting, surveys of helminth infections were conducted in 2003 among individuals who had been under weekly active case detection for clinical malaria during the preceding 18 months in four villages in Kabale District, southwest Uganda. Overall, 47.3% of individuals had at least one intestinal nematode species infection: hookworm, Ascaris lumbricoides and Trichuris trichiura were detected in 32.1, 17.4 and 8.1% of individuals, respectively. We found evidence of significant household clustering of A. lumbricoides, T. trichiura and hookworm, and clustering of heavy infection of each species. The association between helminth infection and clinical malaria was investigated in two villages and no evidence for an association was observed between the presence of infection or heavy infection and risk of malaria.
AB - It has recently been suggested that helminth infections may adversely influence susceptibility to other infections, including malaria. To investigate this hypothesis in a sub-Saharan African setting, surveys of helminth infections were conducted in 2003 among individuals who had been under weekly active case detection for clinical malaria during the preceding 18 months in four villages in Kabale District, southwest Uganda. Overall, 47.3% of individuals had at least one intestinal nematode species infection: hookworm, Ascaris lumbricoides and Trichuris trichiura were detected in 32.1, 17.4 and 8.1% of individuals, respectively. We found evidence of significant household clustering of A. lumbricoides, T. trichiura and hookworm, and clustering of heavy infection of each species. The association between helminth infection and clinical malaria was investigated in two villages and no evidence for an association was observed between the presence of infection or heavy infection and risk of malaria.
KW - Ascaris lumbricoides
KW - Helminths
KW - Hookworm
KW - Malaria
KW - Trichuris trichiura
KW - Uganda
UR - http://www.scopus.com/inward/record.url?scp=8744310145&partnerID=8YFLogxK
U2 - 10.1016/j.trstmh.2004.02.006
DO - 10.1016/j.trstmh.2004.02.006
M3 - Journal article
C2 - 15550257
AN - SCOPUS:8744310145
SN - 0035-9203
VL - 99
SP - 18
EP - 24
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
IS - 1
ER -
