Enteroendocrine cell types revisited

Maja S Engelstoft; Kristoffer Lihme Egerod; Mari L Lund; Thue W Schwartz

doi:10.1016/j.coph.2013.09.018

Enteroendocrine cell types revisited

Maja S Engelstoft, Kristoffer Lihme Egerod, Mari L Lund, Thue W Schwartz

71 Citations (Scopus)

Abstract

The GI-tract is profoundly involved in the control of metabolism through peptide hormones secreted from enteroendocrine cells scattered throughout the gut mucosa. A large number of recently generated transgenic reporter mice have allowed for direct characterization of biochemical and cell biological properties of these previously highly elusive enteroendocrine cells. In particular the surprisingly broad co-expression of six functionally related hormones in the intestinal enteroendocrine cells indicates that it should be possible to control not only the hormone secretion but also the type and number of enteroendocrine cells. However, this will require a more deep understanding of the factors controlling differentiation, gene expression and specification of the enteroendocrine cells during their weekly renewal from progenitor cells in the crypts of the mucosa.

Original language	English
Journal	Current Opinion in Pharmacology
Volume	13
Issue number	6
Pages (from-to)	912-21
Number of pages	10
ISSN	1471-4892
DOIs	https://doi.org/10.1016/j.coph.2013.09.018
Publication status	Published - Dec 2013

Keywords

Animals
Enteroendocrine Cells
Gastrointestinal Hormones
Humans
Intestinal Mucosa
Intestines

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10.1016/j.coph.2013.09.018

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title = "Enteroendocrine cell types revisited",

abstract = "The GI-tract is profoundly involved in the control of metabolism through peptide hormones secreted from enteroendocrine cells scattered throughout the gut mucosa. A large number of recently generated transgenic reporter mice have allowed for direct characterization of biochemical and cell biological properties of these previously highly elusive enteroendocrine cells. In particular the surprisingly broad co-expression of six functionally related hormones in the intestinal enteroendocrine cells indicates that it should be possible to control not only the hormone secretion but also the type and number of enteroendocrine cells. However, this will require a more deep understanding of the factors controlling differentiation, gene expression and specification of the enteroendocrine cells during their weekly renewal from progenitor cells in the crypts of the mucosa.",

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AU - Engelstoft, Maja S

AU - Egerod, Kristoffer Lihme

AU - Lund, Mari L

AU - Schwartz, Thue W

PY - 2013/12

Y1 - 2013/12

N2 - The GI-tract is profoundly involved in the control of metabolism through peptide hormones secreted from enteroendocrine cells scattered throughout the gut mucosa. A large number of recently generated transgenic reporter mice have allowed for direct characterization of biochemical and cell biological properties of these previously highly elusive enteroendocrine cells. In particular the surprisingly broad co-expression of six functionally related hormones in the intestinal enteroendocrine cells indicates that it should be possible to control not only the hormone secretion but also the type and number of enteroendocrine cells. However, this will require a more deep understanding of the factors controlling differentiation, gene expression and specification of the enteroendocrine cells during their weekly renewal from progenitor cells in the crypts of the mucosa.

AB - The GI-tract is profoundly involved in the control of metabolism through peptide hormones secreted from enteroendocrine cells scattered throughout the gut mucosa. A large number of recently generated transgenic reporter mice have allowed for direct characterization of biochemical and cell biological properties of these previously highly elusive enteroendocrine cells. In particular the surprisingly broad co-expression of six functionally related hormones in the intestinal enteroendocrine cells indicates that it should be possible to control not only the hormone secretion but also the type and number of enteroendocrine cells. However, this will require a more deep understanding of the factors controlling differentiation, gene expression and specification of the enteroendocrine cells during their weekly renewal from progenitor cells in the crypts of the mucosa.

KW - Animals

KW - Enteroendocrine Cells

KW - Gastrointestinal Hormones

KW - Humans

KW - Intestinal Mucosa

KW - Intestines

U2 - 10.1016/j.coph.2013.09.018

DO - 10.1016/j.coph.2013.09.018

M3 - Journal article

C2 - 24140256

SN - 1471-4892

VL - 13

SP - 912

EP - 921

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

IS - 6

ER -

Enteroendocrine cell types revisited

Abstract

Keywords

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