Endothelial glycocalyx: shedding light on malaria pathogenesis

Casper Hempel; Erica M Pasini; Jørgen A L Kurtzhals

doi:10.1016/j.molmed.2016.04.004

Endothelial glycocalyx: shedding light on malaria pathogenesis

Casper Hempel, Erica M Pasini, Jørgen A L Kurtzhals

14 Citations (Scopus)

Abstract

Malaria is estimated to kill 438 000 people annually, mostly due to severe malaria, which is closely associated with microcirculatory vasculopathy, although its pathogenesis remains incompletely understood. Here, we propose that the largely ignored glycocalyx of the vascular endothelium plays an important role in facilitating the pathogenesis of severe malaria.

Original language	English
Journal	Trends in Molecular Medicine
Volume	22
Issue number	6
Pages (from-to)	453-457
Number of pages	5
ISSN	1471-4914
DOIs	https://doi.org/10.1016/j.molmed.2016.04.004
Publication status	Published - 1 Jun 2016

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10.1016/j.molmed.2016.04.004

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@article{ffb9e787178b47c593c379237fa256ef,

title = "Endothelial glycocalyx: shedding light on malaria pathogenesis",

abstract = "Malaria is estimated to kill 438 000 people annually, mostly due to severe malaria, which is closely associated with microcirculatory vasculopathy, although its pathogenesis remains incompletely understood. Here, we propose that the largely ignored glycocalyx of the vascular endothelium plays an important role in facilitating the pathogenesis of severe malaria.",

author = "Casper Hempel and Pasini, {Erica M} and Kurtzhals, {J{\o}rgen A L}",

year = "2016",

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T1 - Endothelial glycocalyx

T2 - shedding light on malaria pathogenesis

AU - Hempel, Casper

AU - Pasini, Erica M

AU - Kurtzhals, Jørgen A L

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Malaria is estimated to kill 438 000 people annually, mostly due to severe malaria, which is closely associated with microcirculatory vasculopathy, although its pathogenesis remains incompletely understood. Here, we propose that the largely ignored glycocalyx of the vascular endothelium plays an important role in facilitating the pathogenesis of severe malaria.

AB - Malaria is estimated to kill 438 000 people annually, mostly due to severe malaria, which is closely associated with microcirculatory vasculopathy, although its pathogenesis remains incompletely understood. Here, we propose that the largely ignored glycocalyx of the vascular endothelium plays an important role in facilitating the pathogenesis of severe malaria.

U2 - 10.1016/j.molmed.2016.04.004

DO - 10.1016/j.molmed.2016.04.004

M3 - Journal article

C2 - 27161599

SN - 1471-4914

VL - 22

SP - 453

EP - 457

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

IS - 6

ER -

Endothelial glycocalyx: shedding light on malaria pathogenesis

Abstract

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