Endothelial glycocalyx: shedding light on malaria pathogenesis

TY - JOUR

T1 - Endothelial glycocalyx

T2 - shedding light on malaria pathogenesis

AU - Hempel, Casper

AU - Pasini, Erica M

AU - Kurtzhals, Jørgen A L

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Malaria is estimated to kill 438 000 people annually, mostly due to severe malaria, which is closely associated with microcirculatory vasculopathy, although its pathogenesis remains incompletely understood. Here, we propose that the largely ignored glycocalyx of the vascular endothelium plays an important role in facilitating the pathogenesis of severe malaria.

AB - Malaria is estimated to kill 438 000 people annually, mostly due to severe malaria, which is closely associated with microcirculatory vasculopathy, although its pathogenesis remains incompletely understood. Here, we propose that the largely ignored glycocalyx of the vascular endothelium plays an important role in facilitating the pathogenesis of severe malaria.

U2 - 10.1016/j.molmed.2016.04.004

DO - 10.1016/j.molmed.2016.04.004

M3 - Journal article

C2 - 27161599

SN - 1471-4914

VL - 22

SP - 453

EP - 457

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

IS - 6

ER -