TY - JOUR
T1 - Endothelial cell death and intimal foam cell accumulation in the coronary artery of infected hypercholesterolemic minipigs
AU - Birck, Malene Muusfeldt
AU - Saraste, Antti
AU - Hyttel, Poul
AU - Odermarsky, Michal
AU - Liuba, Petru
AU - Saukko, Pekka
AU - Hansen, Axel Jacob Kornerup
AU - Pesonen, Erkki
PY - 2013/8
Y1 - 2013/8
N2 - Apoptosis of endothelial cells (ECs) has been suggested to play a role in atherosclerosis. We studied the synergism of hypercholesterolemia with Chlamydia pneumoniae and influenza virus infections on EC morphology and intimal changes in a minipig model. The coronary artery was excised at euthanasia (19 weeks of age) and serial sections were processed for the detection of EC apoptosis, histology, and transmission electron microscopy (TEM) studies. There was a significantly higher number of TUNEL-positive ECs in infected compared to noninfected groups [0.2942 % (interquartile ranges (IR), 0.2941; n¿=¿26) versus 0 % (IR, 0; n¿=¿12), p¿
AB - Apoptosis of endothelial cells (ECs) has been suggested to play a role in atherosclerosis. We studied the synergism of hypercholesterolemia with Chlamydia pneumoniae and influenza virus infections on EC morphology and intimal changes in a minipig model. The coronary artery was excised at euthanasia (19 weeks of age) and serial sections were processed for the detection of EC apoptosis, histology, and transmission electron microscopy (TEM) studies. There was a significantly higher number of TUNEL-positive ECs in infected compared to noninfected groups [0.2942 % (interquartile ranges (IR), 0.2941; n¿=¿26) versus 0 % (IR, 0; n¿=¿12), p¿
U2 - 10.1007/s12265-013-9463-2
DO - 10.1007/s12265-013-9463-2
M3 - Journal article
C2 - 23580230
SN - 1937-5387
VL - 6
SP - 579
EP - 587
JO - Journal of Cardiovascular Translational Research
JF - Journal of Cardiovascular Translational Research
IS - 4
ER -