Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse

Edward O. List; Lucila Sackmann-Sala; Darlene E. Berryman; Kevin Funk; Bruce Kelder; Elahu S. Gosney; Shigeru Okada; Juan Ding; Diana Cruz-Topete; John J. Kopchick

doi:10.1210/er.2010-0009

Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse

Edward O. List, Lucila Sackmann-Sala, Darlene E. Berryman, Kevin Funk, Bruce Kelder, Elahu S. Gosney, Shigeru Okada, Juan Ding, Diana Cruz-Topete, John J. Kopchick^*

^*Corresponding author for this work

113 Citations (Scopus)

Abstract

Disruption of the GH receptor (GHR) gene eliminates GH-induced intracellular signaling and, thus, its biological actions. Therefore, the GHR gene disrupted mouse (GHR-/-) has been and is a valuable tool for helping to define various parameters of GH physiology. Since its creation in 1995, this mouse strain has been used by our laboratory and others for numerous studies ranging from growth to aging.Someof the most notable discoveries are their extreme insulin sensitivity in the presence of obesity. Also, the animals haveanextended lifespan, which has generated a large number of investigations into the roles of GH and IGF-I in the aging process. This review summarizes the many results derived from the GHR-/-mice.Wehave attempted to present the findings in the context of current knowledge regarding GH action and, where applicable, to discuss how these mice compare to GH insensitivity syndrome in humans.

Original language	English
Journal	Endocrine Reviews
Volume	32
Issue number	3
Pages (from-to)	356-386
Number of pages	31
ISSN	0163-769X
DOIs	https://doi.org/10.1210/er.2010-0009
Publication status	Published - 1 Jun 2011

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abstract = "Disruption of the GH receptor (GHR) gene eliminates GH-induced intracellular signaling and, thus, its biological actions. Therefore, the GHR gene disrupted mouse (GHR-/-) has been and is a valuable tool for helping to define various parameters of GH physiology. Since its creation in 1995, this mouse strain has been used by our laboratory and others for numerous studies ranging from growth to aging.Someof the most notable discoveries are their extreme insulin sensitivity in the presence of obesity. Also, the animals haveanextended lifespan, which has generated a large number of investigations into the roles of GH and IGF-I in the aging process. This review summarizes the many results derived from the GHR-/-mice.Wehave attempted to present the findings in the context of current knowledge regarding GH action and, where applicable, to discuss how these mice compare to GH insensitivity syndrome in humans.",

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AU - Kelder, Bruce

AU - Gosney, Elahu S.

AU - Okada, Shigeru

AU - Ding, Juan

AU - Cruz-Topete, Diana

AU - Kopchick, John J.

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Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse

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