TY - JOUR
T1 - Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse
AU - List, Edward O.
AU - Sackmann-Sala, Lucila
AU - Berryman, Darlene E.
AU - Funk, Kevin
AU - Kelder, Bruce
AU - Gosney, Elahu S.
AU - Okada, Shigeru
AU - Ding, Juan
AU - Cruz-Topete, Diana
AU - Kopchick, John J.
PY - 2011/6/1
Y1 - 2011/6/1
N2 - Disruption of the GH receptor (GHR) gene eliminates GH-induced intracellular signaling and, thus, its biological actions. Therefore, the GHR gene disrupted mouse (GHR-/-) has been and is a valuable tool for helping to define various parameters of GH physiology. Since its creation in 1995, this mouse strain has been used by our laboratory and others for numerous studies ranging from growth to aging.Someof the most notable discoveries are their extreme insulin sensitivity in the presence of obesity. Also, the animals haveanextended lifespan, which has generated a large number of investigations into the roles of GH and IGF-I in the aging process. This review summarizes the many results derived from the GHR-/-mice.Wehave attempted to present the findings in the context of current knowledge regarding GH action and, where applicable, to discuss how these mice compare to GH insensitivity syndrome in humans.
AB - Disruption of the GH receptor (GHR) gene eliminates GH-induced intracellular signaling and, thus, its biological actions. Therefore, the GHR gene disrupted mouse (GHR-/-) has been and is a valuable tool for helping to define various parameters of GH physiology. Since its creation in 1995, this mouse strain has been used by our laboratory and others for numerous studies ranging from growth to aging.Someof the most notable discoveries are their extreme insulin sensitivity in the presence of obesity. Also, the animals haveanextended lifespan, which has generated a large number of investigations into the roles of GH and IGF-I in the aging process. This review summarizes the many results derived from the GHR-/-mice.Wehave attempted to present the findings in the context of current knowledge regarding GH action and, where applicable, to discuss how these mice compare to GH insensitivity syndrome in humans.
UR - http://www.scopus.com/inward/record.url?scp=79958243025&partnerID=8YFLogxK
U2 - 10.1210/er.2010-0009
DO - 10.1210/er.2010-0009
M3 - Review
C2 - 21123740
AN - SCOPUS:79958243025
SN - 0163-769X
VL - 32
SP - 356
EP - 386
JO - Endocrine Reviews
JF - Endocrine Reviews
IS - 3
ER -
