Enantioselective Fluorination of Spirocyclic β-Prolinals Using Enamine Catalysis

Kasper Fjelbye; Mauro Marigo; Rasmus Prætorius Clausen; Karsten Juhl

doi:10.1055/s-0036-1588100

Enantioselective Fluorination of Spirocyclic β-Prolinals Using Enamine Catalysis

Kasper Fjelbye^*, Mauro Marigo, Rasmus Prætorius Clausen, Karsten Juhl

^*Corresponding author for this work

7 Citations (Scopus)

Abstract

A series of spirocyclic carbaldehydes were successfully fluorinated using enamine catalysis, furnishing the corresponding tertiary fluorides in both high yields and enantioselectivities. The fluorinated spirocycles provide a set of novel building blocks interesting from a medicinal chemistry point of view.

Original language	English
Article number	st-2016-b0535-l
Journal	SYNLETT: Accounts and Rapid Communications in Chemical Synthesis
Volume	28
Issue number	4
Pages (from-to)	425-428
Number of pages	4
ISSN	0936-5214
DOIs	https://doi.org/10.1055/s-0036-1588100
Publication status	Published - 2017

Keywords

asymmetric synthesis
enantioselective catalysis
fluorination
organocatalysis
spirocycles

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10.1055/s-0036-1588100

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title = "Enantioselective Fluorination of Spirocyclic β-Prolinals Using Enamine Catalysis",

abstract = "A series of spirocyclic carbaldehydes were successfully fluorinated using enamine catalysis, furnishing the corresponding tertiary fluorides in both high yields and enantioselectivities. The fluorinated spirocycles provide a set of novel building blocks interesting from a medicinal chemistry point of view.",

keywords = "asymmetric synthesis, enantioselective catalysis, fluorination, organocatalysis, spirocycles",

author = "Kasper Fjelbye and Mauro Marigo and Clausen, {Rasmus Pr{\ae}torius} and Karsten Juhl",

year = "2017",

doi = "10.1055/s-0036-1588100",

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TY - JOUR

T1 - Enantioselective Fluorination of Spirocyclic β-Prolinals Using Enamine Catalysis

AU - Fjelbye, Kasper

AU - Marigo, Mauro

AU - Clausen, Rasmus Prætorius

AU - Juhl, Karsten

PY - 2017

Y1 - 2017

N2 - A series of spirocyclic carbaldehydes were successfully fluorinated using enamine catalysis, furnishing the corresponding tertiary fluorides in both high yields and enantioselectivities. The fluorinated spirocycles provide a set of novel building blocks interesting from a medicinal chemistry point of view.

AB - A series of spirocyclic carbaldehydes were successfully fluorinated using enamine catalysis, furnishing the corresponding tertiary fluorides in both high yields and enantioselectivities. The fluorinated spirocycles provide a set of novel building blocks interesting from a medicinal chemistry point of view.

KW - asymmetric synthesis

KW - enantioselective catalysis

KW - fluorination

KW - organocatalysis

KW - spirocycles

U2 - 10.1055/s-0036-1588100

DO - 10.1055/s-0036-1588100

M3 - Journal article

AN - SCOPUS:84995470829

SN - 0936-5214

VL - 28

SP - 425

EP - 428

JO - SYNLETT: Accounts and Rapid Communications in Chemical Synthesis

JF - SYNLETT: Accounts and Rapid Communications in Chemical Synthesis

IS - 4

M1 - st-2016-b0535-l

ER -

Enantioselective Fluorination of Spirocyclic β-Prolinals Using Enamine Catalysis

Abstract

Keywords

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