Emerging properties and functional consequences of noncoding transcription

Ryan Ard; Robin C Allshire; Sebastian Marquardt

doi:10.1534/genetics.117.300095

Emerging properties and functional consequences of noncoding transcription

Ryan Ard, Robin C Allshire, Sebastian Marquardt

25 Citations (Scopus)

Abstract

Eukaryotic genomes are rich in transcription units encoding "long noncoding RNAs" (lncRNAs). The purpose of all this transcription is unclear since most lncRNAs are quickly targeted for destruction during synthesis or shortly thereafter. As debates continue over the functional significance of many specific lncRNAs, support grows for the notion that the act of transcription rather than the RNA product itself is functionally important in many cases. Indeed, this alternative mechanism might better explain how low-abundance lncRNAs transcribed from noncoding DNA function in organisms. Here, we highlight some of the recently emerging features that distinguish coding from noncoding transcription and discuss how these differences might have important implications for the functional consequences of noncoding transcription.

Original language	English
Journal	Genetics
Volume	207
Issue number	2
Pages (from-to)	357-367
Number of pages	11
ISSN	1943-2631
DOIs	https://doi.org/10.1534/genetics.117.300095
Publication status	Published - Oct 2017

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Emerging properties and functional consequences of noncoding transcription

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