Emerging properties and functional consequences of noncoding transcription

Ryan Ard; Robin C Allshire; Sebastian Marquardt

doi:10.1534/genetics.117.300095

Emerging properties and functional consequences of noncoding transcription

Ryan Ard, Robin C Allshire, Sebastian Marquardt

25 Citationer (Scopus)

Abstract

Eukaryotic genomes are rich in transcription units encoding "long noncoding RNAs" (lncRNAs). The purpose of all this transcription is unclear since most lncRNAs are quickly targeted for destruction during synthesis or shortly thereafter. As debates continue over the functional significance of many specific lncRNAs, support grows for the notion that the act of transcription rather than the RNA product itself is functionally important in many cases. Indeed, this alternative mechanism might better explain how low-abundance lncRNAs transcribed from noncoding DNA function in organisms. Here, we highlight some of the recently emerging features that distinguish coding from noncoding transcription and discuss how these differences might have important implications for the functional consequences of noncoding transcription.

Originalsprog	Engelsk
Tidsskrift	Genetics
Vol/bind	207
Udgave nummer	2
Sider (fra-til)	357-367
Antal sider	11
ISSN	1943-2631
DOI	https://doi.org/10.1534/genetics.117.300095
Status	Udgivet - okt. 2017

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10.1534/genetics.117.300095

Emerging Properties and Functional Consequences of Noncoding TranscriptionForlagets udgivne version, 1,1 MB

Citationsformater

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Emerging properties and functional consequences of noncoding transcription

Abstract

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