Embolic encephalitis in a porcine model of endocarditis

Johanna Kristina G Christiansen; Malin Oscarson; Henrik Elvang Jensen; Louise Kruse Johansen; Janne Koch; Bent Aalbæk; Ole Lerberg Nielsen; Tine Moesgaard Iburg; Páll S. Leifsson

Embolic encephalitis in a porcine model of endocarditis

Johanna Kristina G Christiansen, Malin Oscarson, Henrik Elvang Jensen, Louise Kruse Johansen, Janne Koch, Bent Aalbæk, Ole Lerberg Nielsen, Tine Moesgaard Iburg, Páll S. Leifsson

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Abstract

Background: Endocarditis is a severe disease in which neurological complications are frequent and associated with increased mortality and complex disease management. In the present study, the pig was evaluated as a model of embolic encephalitis as a complication of experimental infective endocarditis. Materials and Methods: Brains from pigs with experimental Staphylococcus aureus-associated infective endocarditis (IE; n=2), experimental non-bacterial thrombotic endocarditis (NBTE; n=5), experimental S. aureus sepsis without endocarditis (SNE; n=3) and saline controls (n=3), were used. The brains were examined for lesions macroscopically, histologically and immunohistochemically. Results: Lesions of focal encephalitis were found in the IE and SNE pigs, at considerably higher numbers in the IE pigs. Furthermore, microabscesses were common in the IE pigs, which fits the association between brain abscesses and S. aureus-associated endocarditis in humans. Conclusion: Experimental porcine S. aureus-associated endocarditis is advantageous for studying neurological complications, such as brain abscess formation, as a result of endocardial bacterial seeding.

Original language	English
Journal	In Vivo
Volume	27
Issue number	5
Pages (from-to)	591-597
Number of pages	7
ISSN	0258-851X
Publication status	Published - 2013

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title = "Embolic encephalitis in a porcine model of endocarditis",

abstract = "Background: Endocarditis is a severe disease in which neurological complications are frequent and associated with increased mortality and complex disease management. In the present study, the pig was evaluated as a model of embolic encephalitis as a complication of experimental infective endocarditis. Materials and Methods: Brains from pigs with experimental Staphylococcus aureus-associated infective endocarditis (IE; n=2), experimental non-bacterial thrombotic endocarditis (NBTE; n=5), experimental S. aureus sepsis without endocarditis (SNE; n=3) and saline controls (n=3), were used. The brains were examined for lesions macroscopically, histologically and immunohistochemically. Results: Lesions of focal encephalitis were found in the IE and SNE pigs, at considerably higher numbers in the IE pigs. Furthermore, microabscesses were common in the IE pigs, which fits the association between brain abscesses and S. aureus-associated endocarditis in humans. Conclusion: Experimental porcine S. aureus-associated endocarditis is advantageous for studying neurological complications, such as brain abscess formation, as a result of endocardial bacterial seeding.",

author = "Christiansen, {Johanna Kristina G} and Malin Oscarson and Jensen, {Henrik Elvang} and Johansen, {Louise Kruse} and Janne Koch and Bent Aalb{\ae}k and Nielsen, {Ole Lerberg} and Iburg, {Tine Moesgaard} and Leifsson, {P{\'a}ll S.}",

year = "2013",

language = "English",

volume = "27",

pages = "591--597",

journal = "In Vivo",

issn = "0258-851X",

publisher = "International Institute of Anticancer Research",

number = "5",

}

TY - JOUR

T1 - Embolic encephalitis in a porcine model of endocarditis

AU - Christiansen, Johanna Kristina G

AU - Oscarson, Malin

AU - Jensen, Henrik Elvang

AU - Johansen, Louise Kruse

AU - Koch, Janne

AU - Aalbæk, Bent

AU - Nielsen, Ole Lerberg

AU - Iburg, Tine Moesgaard

AU - Leifsson, Páll S.

PY - 2013

Y1 - 2013

N2 - Background: Endocarditis is a severe disease in which neurological complications are frequent and associated with increased mortality and complex disease management. In the present study, the pig was evaluated as a model of embolic encephalitis as a complication of experimental infective endocarditis. Materials and Methods: Brains from pigs with experimental Staphylococcus aureus-associated infective endocarditis (IE; n=2), experimental non-bacterial thrombotic endocarditis (NBTE; n=5), experimental S. aureus sepsis without endocarditis (SNE; n=3) and saline controls (n=3), were used. The brains were examined for lesions macroscopically, histologically and immunohistochemically. Results: Lesions of focal encephalitis were found in the IE and SNE pigs, at considerably higher numbers in the IE pigs. Furthermore, microabscesses were common in the IE pigs, which fits the association between brain abscesses and S. aureus-associated endocarditis in humans. Conclusion: Experimental porcine S. aureus-associated endocarditis is advantageous for studying neurological complications, such as brain abscess formation, as a result of endocardial bacterial seeding.

AB - Background: Endocarditis is a severe disease in which neurological complications are frequent and associated with increased mortality and complex disease management. In the present study, the pig was evaluated as a model of embolic encephalitis as a complication of experimental infective endocarditis. Materials and Methods: Brains from pigs with experimental Staphylococcus aureus-associated infective endocarditis (IE; n=2), experimental non-bacterial thrombotic endocarditis (NBTE; n=5), experimental S. aureus sepsis without endocarditis (SNE; n=3) and saline controls (n=3), were used. The brains were examined for lesions macroscopically, histologically and immunohistochemically. Results: Lesions of focal encephalitis were found in the IE and SNE pigs, at considerably higher numbers in the IE pigs. Furthermore, microabscesses were common in the IE pigs, which fits the association between brain abscesses and S. aureus-associated endocarditis in humans. Conclusion: Experimental porcine S. aureus-associated endocarditis is advantageous for studying neurological complications, such as brain abscess formation, as a result of endocardial bacterial seeding.

M3 - Journal article

SN - 0258-851X

VL - 27

SP - 591

EP - 597

JO - In Vivo

JF - In Vivo

IS - 5

ER -

Embolic encephalitis in a porcine model of endocarditis

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