Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance

Morten Petersen; P. Brodersen; H. Naested; E. Andreasson; U. Lindhart; Bo Johansen; Henrik B. Nielsen; M. Lacy; M.J. Austin; J.E. Parker; S.B. Sharma; D.F. Klessig; R. Martienssen; O. Mattsson; A.B. Jensen; John Williams Mundy

doi:10.1016/S0092-8674(00)00213-0

Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance

Morten Petersen, P. Brodersen, H. Naested, E. Andreasson, U. Lindhart, Bo Johansen, Henrik B. Nielsen, M. Lacy, M.J. Austin, J.E. Parker, S.B. Sharma, D.F. Klessig, R. Martienssen, O. Mattsson, A.B. Jensen, John Williams Mundy

735 Citations (Scopus)

Abstract

Transposon inactivation of Arabidopsis MAP kinase 4 produced the mpk4 mutant exhibiting constitutive systemic acquired resistance (SAR) including elevated salicylic acid (SA) levels, increased resistance to virulent pathogens, and constitutive pathogenesis-related gene expression shown by Northern and microarray hybridizations. MPK4 kinase activity is required to repress SAR, as an inactive MPK4 form failed to complement mpk4. Analysis of mpk4 expressing the SA hydroxylase NahG and of mpk4/npr1 double mutants indicated that SAR expression in mpk4 is dependent upon elevated SA levels but is independent of NPR1. PDF1.2 and THI2.1 gene induction by jasmonate was blocked in mpk4 expressing NahG, suggesting that MPK4 is required for jasmonic acid-responsive gene expression.

Original language	English
Journal	Gekkan Saibo
Volume	103
Issue number	7
Pages (from-to)	1111-1120
ISSN	0386-4766
DOIs	https://doi.org/10.1016/S0092-8674(00)00213-0
Publication status	Published - 2000

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Petersen, M., Brodersen, P., Naested, H., Andreasson, E., Lindhart, U., Johansen, B., Nielsen, H. B., Lacy, M., Austin, M. J., Parker, J. E., Sharma, S. B., Klessig, D. F., Martienssen, R., Mattsson, O., Jensen, A. B., & Mundy, J. W. (2000). Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance. Gekkan Saibo, 103(7), 1111-1120. https://doi.org/10.1016/S0092-8674(00)00213-0

Petersen, M, Brodersen, P, Naested, H, Andreasson, E, Lindhart, U, Johansen, B, Nielsen, HB, Lacy, M, Austin, MJ, Parker, JE, Sharma, SB, Klessig, DF, Martienssen, R, Mattsson, O, Jensen, AB & Mundy, JW 2000, 'Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance', Gekkan Saibo, vol. 103, no. 7, pp. 1111-1120. https://doi.org/10.1016/S0092-8674(00)00213-0

@article{54947be074c811dbbee902004c4f4f50,

title = "Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance",

abstract = "Transposon inactivation of Arabidopsis MAP kinase 4 produced the mpk4 mutant exhibiting constitutive systemic acquired resistance (SAR) including elevated salicylic acid (SA) levels, increased resistance to virulent pathogens, and constitutive pathogenesis-related gene expression shown by Northern and microarray hybridizations. MPK4 kinase activity is required to repress SAR, as an inactive MPK4 form failed to complement mpk4. Analysis of mpk4 expressing the SA hydroxylase NahG and of mpk4/npr1 double mutants indicated that SAR expression in mpk4 is dependent upon elevated SA levels but is independent of NPR1. PDF1.2 and THI2.1 gene induction by jasmonate was blocked in mpk4 expressing NahG, suggesting that MPK4 is required for jasmonic acid-responsive gene expression.",

author = "Morten Petersen and P. Brodersen and H. Naested and E. Andreasson and U. Lindhart and Bo Johansen and Nielsen, {Henrik B.} and M. Lacy and M.J. Austin and J.E. Parker and S.B. Sharma and D.F. Klessig and R. Martienssen and O. Mattsson and A.B. Jensen and Mundy, {John Williams}",

year = "2000",

doi = "10.1016/S0092-8674(00)00213-0",

language = "English",

volume = "103",

pages = "1111--1120",

journal = "Gekkan Saibo",

issn = "0386-4766",

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TY - JOUR

T1 - Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance

AU - Petersen, Morten

AU - Brodersen, P.

AU - Naested, H.

AU - Andreasson, E.

AU - Lindhart, U.

AU - Johansen, Bo

AU - Nielsen, Henrik B.

AU - Lacy, M.

AU - Austin, M.J.

AU - Parker, J.E.

AU - Sharma, S.B.

AU - Klessig, D.F.

AU - Martienssen, R.

AU - Mattsson, O.

AU - Jensen, A.B.

AU - Mundy, John Williams

PY - 2000

Y1 - 2000

N2 - Transposon inactivation of Arabidopsis MAP kinase 4 produced the mpk4 mutant exhibiting constitutive systemic acquired resistance (SAR) including elevated salicylic acid (SA) levels, increased resistance to virulent pathogens, and constitutive pathogenesis-related gene expression shown by Northern and microarray hybridizations. MPK4 kinase activity is required to repress SAR, as an inactive MPK4 form failed to complement mpk4. Analysis of mpk4 expressing the SA hydroxylase NahG and of mpk4/npr1 double mutants indicated that SAR expression in mpk4 is dependent upon elevated SA levels but is independent of NPR1. PDF1.2 and THI2.1 gene induction by jasmonate was blocked in mpk4 expressing NahG, suggesting that MPK4 is required for jasmonic acid-responsive gene expression.

AB - Transposon inactivation of Arabidopsis MAP kinase 4 produced the mpk4 mutant exhibiting constitutive systemic acquired resistance (SAR) including elevated salicylic acid (SA) levels, increased resistance to virulent pathogens, and constitutive pathogenesis-related gene expression shown by Northern and microarray hybridizations. MPK4 kinase activity is required to repress SAR, as an inactive MPK4 form failed to complement mpk4. Analysis of mpk4 expressing the SA hydroxylase NahG and of mpk4/npr1 double mutants indicated that SAR expression in mpk4 is dependent upon elevated SA levels but is independent of NPR1. PDF1.2 and THI2.1 gene induction by jasmonate was blocked in mpk4 expressing NahG, suggesting that MPK4 is required for jasmonic acid-responsive gene expression.

U2 - 10.1016/S0092-8674(00)00213-0

DO - 10.1016/S0092-8674(00)00213-0

M3 - Journal article

SN - 0386-4766

VL - 103

SP - 1111

EP - 1120

JO - Gekkan Saibo

JF - Gekkan Saibo

IS - 7

ER -

Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance

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