@article{54947be074c811dbbee902004c4f4f50,
title = "Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance",
abstract = "Transposon inactivation of Arabidopsis MAP kinase 4 produced the mpk4 mutant exhibiting constitutive systemic acquired resistance (SAR) including elevated salicylic acid (SA) levels, increased resistance to virulent pathogens, and constitutive pathogenesis-related gene expression shown by Northern and microarray hybridizations. MPK4 kinase activity is required to repress SAR, as an inactive MPK4 form failed to complement mpk4. Analysis of mpk4 expressing the SA hydroxylase NahG and of mpk4/npr1 double mutants indicated that SAR expression in mpk4 is dependent upon elevated SA levels but is independent of NPR1. PDF1.2 and THI2.1 gene induction by jasmonate was blocked in mpk4 expressing NahG, suggesting that MPK4 is required for jasmonic acid-responsive gene expression.",
author = "Morten Petersen and P. Brodersen and H. Naested and E. Andreasson and U. Lindhart and Bo Johansen and Nielsen, {Henrik B.} and M. Lacy and M.J. Austin and J.E. Parker and S.B. Sharma and D.F. Klessig and R. Martienssen and O. Mattsson and A.B. Jensen and Mundy, {John Williams}",
year = "2000",
doi = "10.1016/S0092-8674(00)00213-0",
language = "English",
volume = "103",
pages = "1111--1120",
journal = "Gekkan Saibo",
issn = "0386-4766",
publisher = "Nyu Saiensusha",
number = "7",
}