Elevated Renal Oxygen Extraction During Open Abdominal Aortic Aneurysm Repair Is Related to Postoperative Renal Dysfunction

Niels Damkjær Olesen; Thomas Bech Jørgensen; Jonas Eiberg; Ulf Johan Vilhelm Helgstrand; Henrik Hegaard Sillesen; Pernille Cedergreen; Niels Henry Secher; Henning Bay Nielsen

doi:10.1177/1089253218790270

Elevated Renal Oxygen Extraction During Open Abdominal Aortic Aneurysm Repair Is Related to Postoperative Renal Dysfunction

Niels Damkjær Olesen, Thomas Bech Jørgensen, Jonas Eiberg, Ulf Johan Vilhelm Helgstrand, Henrik Hegaard Sillesen, Pernille Cedergreen, Niels Henry Secher, Henning Bay Nielsen

Department of Clinical Medicine

2 Citations (Scopus)

Abstract

Background. Open abdominal aortic aneurysm repair is often followed by elevated plasma creatinine, likely due to impaired renal blood flow. We evaluated whether postoperative elevation in creatinine relates to renal oxygen extraction during surgery as an index of renal blood flow and also monitored frontal lobe oxygenation. Methods. For 19 patients (66 ± 10 years; mean ± SD) undergoing open infrarenal abdominal aortic aneurysm repair, renal oxygen extraction was determined by arterial and renal vein catheterization. Near-infrared spectroscopy determined frontal lobe oxygenation. Results. During surgery mean arterial pressure (from 102 ± 14 to 65 ± 11 mm Hg; P <.0001), arterial hemoglobin (from 7.7 ± 0.7 to 6.6 ± 0.8 mmol/L; P < 0.0001), and frontal lobe oxygenation (from 74 ± 6% to 70 ± 6%; P =.0414) decreased, while renal oxygen extraction increased (from 5.3% [4.3-8.1]; median [interquartile range] to 10.8% [5.8-17.5]; P =.0405). Plasma creatinine became significantly elevated on the second day after the operation (from 83 [73-101] to 105 µmol/L [79-143]; P =.0062) with a peak increase observed after 2 days (1-2). The peak increase in creatinine correlated to intraoperative renal oxygen extraction (r = 0.51; P =.026). Conclusion. Kidney function was affected after open abdominal aortic aneurysm repair likely related to limited renal blood flow. We take the increase in renal oxygen extraction and reduction in frontal lobe oxygenation to suggest that mean arterial pressure and hemoglobin were too low to maintain renal and cerebral circulation in vascular surgical patients.

Original language	English
Journal	Seminars in Cardiothoracic and Vascular Anesthesia
Volume	22
Issue number	4
Pages (from-to)	369-375
ISSN	1089-2532
DOIs	https://doi.org/10.1177/1089253218790270
Publication status	Published - 1 Dec 2018

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Olesen, N. D., Jørgensen, T. B., Eiberg, J., Helgstrand, U. J. V., Sillesen, H. H., Cedergreen, P., Secher, N. H., & Nielsen, H. B. (2018). Elevated Renal Oxygen Extraction During Open Abdominal Aortic Aneurysm Repair Is Related to Postoperative Renal Dysfunction. Seminars in Cardiothoracic and Vascular Anesthesia, 22(4), 369-375. https://doi.org/10.1177/1089253218790270

Elevated Renal Oxygen Extraction During Open Abdominal Aortic Aneurysm Repair Is Related to Postoperative Renal Dysfunction. / Olesen, Niels Damkjær; Jørgensen, Thomas Bech; Eiberg, Jonas et al.
In: Seminars in Cardiothoracic and Vascular Anesthesia, Vol. 22, No. 4, 01.12.2018, p. 369-375.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Elevated Renal Oxygen Extraction During Open Abdominal Aortic Aneurysm Repair Is Related to Postoperative Renal Dysfunction",

abstract = "Background. Open abdominal aortic aneurysm repair is often followed by elevated plasma creatinine, likely due to impaired renal blood flow. We evaluated whether postoperative elevation in creatinine relates to renal oxygen extraction during surgery as an index of renal blood flow and also monitored frontal lobe oxygenation. Methods. For 19 patients (66 ± 10 years; mean ± SD) undergoing open infrarenal abdominal aortic aneurysm repair, renal oxygen extraction was determined by arterial and renal vein catheterization. Near-infrared spectroscopy determined frontal lobe oxygenation. Results. During surgery mean arterial pressure (from 102 ± 14 to 65 ± 11 mm Hg; P <.0001), arterial hemoglobin (from 7.7 ± 0.7 to 6.6 ± 0.8 mmol/L; P < 0.0001), and frontal lobe oxygenation (from 74 ± 6% to 70 ± 6%; P =.0414) decreased, while renal oxygen extraction increased (from 5.3% [4.3-8.1]; median [interquartile range] to 10.8% [5.8-17.5]; P =.0405). Plasma creatinine became significantly elevated on the second day after the operation (from 83 [73-101] to 105 µmol/L [79-143]; P =.0062) with a peak increase observed after 2 days (1-2). The peak increase in creatinine correlated to intraoperative renal oxygen extraction (r = 0.51; P =.026). Conclusion. Kidney function was affected after open abdominal aortic aneurysm repair likely related to limited renal blood flow. We take the increase in renal oxygen extraction and reduction in frontal lobe oxygenation to suggest that mean arterial pressure and hemoglobin were too low to maintain renal and cerebral circulation in vascular surgical patients.",

author = "Olesen, {Niels Damkj{\ae}r} and J{\o}rgensen, {Thomas Bech} and Jonas Eiberg and Helgstrand, {Ulf Johan Vilhelm} and Sillesen, {Henrik Hegaard} and Pernille Cedergreen and Secher, {Niels Henry} and Nielsen, {Henning Bay}",

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doi = "10.1177/1089253218790270",

language = "English",

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T1 - Elevated Renal Oxygen Extraction During Open Abdominal Aortic Aneurysm Repair Is Related to Postoperative Renal Dysfunction

AU - Olesen, Niels Damkjær

AU - Jørgensen, Thomas Bech

AU - Eiberg, Jonas

AU - Helgstrand, Ulf Johan Vilhelm

AU - Sillesen, Henrik Hegaard

AU - Cedergreen, Pernille

AU - Secher, Niels Henry

AU - Nielsen, Henning Bay

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background. Open abdominal aortic aneurysm repair is often followed by elevated plasma creatinine, likely due to impaired renal blood flow. We evaluated whether postoperative elevation in creatinine relates to renal oxygen extraction during surgery as an index of renal blood flow and also monitored frontal lobe oxygenation. Methods. For 19 patients (66 ± 10 years; mean ± SD) undergoing open infrarenal abdominal aortic aneurysm repair, renal oxygen extraction was determined by arterial and renal vein catheterization. Near-infrared spectroscopy determined frontal lobe oxygenation. Results. During surgery mean arterial pressure (from 102 ± 14 to 65 ± 11 mm Hg; P <.0001), arterial hemoglobin (from 7.7 ± 0.7 to 6.6 ± 0.8 mmol/L; P < 0.0001), and frontal lobe oxygenation (from 74 ± 6% to 70 ± 6%; P =.0414) decreased, while renal oxygen extraction increased (from 5.3% [4.3-8.1]; median [interquartile range] to 10.8% [5.8-17.5]; P =.0405). Plasma creatinine became significantly elevated on the second day after the operation (from 83 [73-101] to 105 µmol/L [79-143]; P =.0062) with a peak increase observed after 2 days (1-2). The peak increase in creatinine correlated to intraoperative renal oxygen extraction (r = 0.51; P =.026). Conclusion. Kidney function was affected after open abdominal aortic aneurysm repair likely related to limited renal blood flow. We take the increase in renal oxygen extraction and reduction in frontal lobe oxygenation to suggest that mean arterial pressure and hemoglobin were too low to maintain renal and cerebral circulation in vascular surgical patients.

AB - Background. Open abdominal aortic aneurysm repair is often followed by elevated plasma creatinine, likely due to impaired renal blood flow. We evaluated whether postoperative elevation in creatinine relates to renal oxygen extraction during surgery as an index of renal blood flow and also monitored frontal lobe oxygenation. Methods. For 19 patients (66 ± 10 years; mean ± SD) undergoing open infrarenal abdominal aortic aneurysm repair, renal oxygen extraction was determined by arterial and renal vein catheterization. Near-infrared spectroscopy determined frontal lobe oxygenation. Results. During surgery mean arterial pressure (from 102 ± 14 to 65 ± 11 mm Hg; P <.0001), arterial hemoglobin (from 7.7 ± 0.7 to 6.6 ± 0.8 mmol/L; P < 0.0001), and frontal lobe oxygenation (from 74 ± 6% to 70 ± 6%; P =.0414) decreased, while renal oxygen extraction increased (from 5.3% [4.3-8.1]; median [interquartile range] to 10.8% [5.8-17.5]; P =.0405). Plasma creatinine became significantly elevated on the second day after the operation (from 83 [73-101] to 105 µmol/L [79-143]; P =.0062) with a peak increase observed after 2 days (1-2). The peak increase in creatinine correlated to intraoperative renal oxygen extraction (r = 0.51; P =.026). Conclusion. Kidney function was affected after open abdominal aortic aneurysm repair likely related to limited renal blood flow. We take the increase in renal oxygen extraction and reduction in frontal lobe oxygenation to suggest that mean arterial pressure and hemoglobin were too low to maintain renal and cerebral circulation in vascular surgical patients.

U2 - 10.1177/1089253218790270

DO - 10.1177/1089253218790270

M3 - Journal article

C2 - 30047299

SN - 1089-2532

VL - 22

SP - 369

EP - 375

JO - Seminars in Cardiothoracic and Vascular Anesthesia

JF - Seminars in Cardiothoracic and Vascular Anesthesia

IS - 4

ER -

Elevated Renal Oxygen Extraction During Open Abdominal Aortic Aneurysm Repair Is Related to Postoperative Renal Dysfunction

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