Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon

P B Jeppesen; B Hartmann; J Thulesen; B S Hansen; J J Holst; Steen Seier Poulsen; P B Mortensen

Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon

P B Jeppesen, B Hartmann, J Thulesen, B S Hansen, J J Holst, Steen Seier Poulsen, P B Mortensen

141 Citations (Scopus)

Abstract

The glucagon-like peptides (GLP) 1 and 2 are secreted postprandially from L cells located mainly in the ileum. Both hormones prolong intestinal transit and GLP-2 is intestinotrophic in rodents. Patients with a jejunostomy have poor adaptation, rapid gastric and intestinal transit, and impaired postprandial GLP-2 secretion. Ileum resected short bowel patients with a preserved colon show evidence of functional adaptation and have normal gastric emptying.

Original language	English
Journal	Gut
Volume	47
Issue number	3
Pages (from-to)	370-6
Number of pages	7
ISSN	0017-5749
Publication status	Published - Sept 2000

Keywords

Adaptation, Physiological
Adult
Aged
Area Under Curve
Case-Control Studies
Fasting
Female
Glucagon
Glucagon-Like Peptide 1
Glucagon-Like Peptide 2
Humans
Ileum
Male
Middle Aged
Peptide Fragments
Peptides
Postprandial Period
Protein Precursors
Radioimmunoassay
Short Bowel Syndrome

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title = "Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon",

abstract = "The glucagon-like peptides (GLP) 1 and 2 are secreted postprandially from L cells located mainly in the ileum. Both hormones prolong intestinal transit and GLP-2 is intestinotrophic in rodents. Patients with a jejunostomy have poor adaptation, rapid gastric and intestinal transit, and impaired postprandial GLP-2 secretion. Ileum resected short bowel patients with a preserved colon show evidence of functional adaptation and have normal gastric emptying.",

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author = "Jeppesen, {P B} and B Hartmann and J Thulesen and Hansen, {B S} and Holst, {J J} and Poulsen, {Steen Seier} and Mortensen, {P B}",

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month = sep,

language = "English",

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pages = "370--6",

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T1 - Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon

AU - Jeppesen, P B

AU - Hartmann, B

AU - Thulesen, J

AU - Hansen, B S

AU - Holst, J J

AU - Poulsen, Steen Seier

AU - Mortensen, P B

PY - 2000/9

Y1 - 2000/9

N2 - The glucagon-like peptides (GLP) 1 and 2 are secreted postprandially from L cells located mainly in the ileum. Both hormones prolong intestinal transit and GLP-2 is intestinotrophic in rodents. Patients with a jejunostomy have poor adaptation, rapid gastric and intestinal transit, and impaired postprandial GLP-2 secretion. Ileum resected short bowel patients with a preserved colon show evidence of functional adaptation and have normal gastric emptying.

AB - The glucagon-like peptides (GLP) 1 and 2 are secreted postprandially from L cells located mainly in the ileum. Both hormones prolong intestinal transit and GLP-2 is intestinotrophic in rodents. Patients with a jejunostomy have poor adaptation, rapid gastric and intestinal transit, and impaired postprandial GLP-2 secretion. Ileum resected short bowel patients with a preserved colon show evidence of functional adaptation and have normal gastric emptying.

KW - Adaptation, Physiological

KW - Adult

KW - Aged

KW - Area Under Curve

KW - Case-Control Studies

KW - Fasting

KW - Female

KW - Glucagon

KW - Glucagon-Like Peptide 1

KW - Glucagon-Like Peptide 2

KW - Humans

KW - Ileum

KW - Male

KW - Middle Aged

KW - Peptide Fragments

KW - Peptides

KW - Postprandial Period

KW - Protein Precursors

KW - Radioimmunoassay

KW - Short Bowel Syndrome

M3 - Journal article

C2 - 10940274

SN - 0017-5749

VL - 47

SP - 370

EP - 376

JO - Gut

JF - Gut

IS - 3

ER -

Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon

Abstract

Keywords

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