Elevated C-reactive protein and late-onset bipolar disorder in 78 809 individuals from the general population

TY - JOUR

T1 - Elevated C-reactive protein and late-onset bipolar disorder in 78 809 individuals from the general population

AU - Wium-Andersen, Marie Kim

AU - Ørsted, David Dynnes

AU - Nordestgaard, Børge Grønne

N1 - © The Royal College of Psychiatrists 2016.

PY - 2016/2

Y1 - 2016/2

N2 - BACKGROUND: No prospective studies have examined the role of C-reactive protein (CRP) in late-onset bipolar disorder.AIMS: We tested the hypothesis that elevated levels of CRP are associated cross-sectionally and prospectively with late-onset bipolar disorder, and that such an association possibly is causal.METHOD: We performed cross-sectional and prospective analyses with a median follow-up time of 5.9 years (interquartile range: 4.4-7.6) in 78 809 individuals from the general population, and used genetic variants influencing CRP levels to perform a Mendelian randomisation study.RESULTS: Elevated levels of CRP were associated both cross-sectionally and prospectively with late-onset bipolar disorder. When CRP was on a continuous scale, a doubling in CRP yielded an observational odds ratio for late-onset bipolar disorder of 1.28 (1.08-1.52) with a corresponding causal odds ratio of 4.66 (0.89-24.3).CONCLUSION: Elevated CRP is associated with increased risk of late-onset bipolar disorder in the general population which was supported by the genetic analysis.

AB - BACKGROUND: No prospective studies have examined the role of C-reactive protein (CRP) in late-onset bipolar disorder.AIMS: We tested the hypothesis that elevated levels of CRP are associated cross-sectionally and prospectively with late-onset bipolar disorder, and that such an association possibly is causal.METHOD: We performed cross-sectional and prospective analyses with a median follow-up time of 5.9 years (interquartile range: 4.4-7.6) in 78 809 individuals from the general population, and used genetic variants influencing CRP levels to perform a Mendelian randomisation study.RESULTS: Elevated levels of CRP were associated both cross-sectionally and prospectively with late-onset bipolar disorder. When CRP was on a continuous scale, a doubling in CRP yielded an observational odds ratio for late-onset bipolar disorder of 1.28 (1.08-1.52) with a corresponding causal odds ratio of 4.66 (0.89-24.3).CONCLUSION: Elevated CRP is associated with increased risk of late-onset bipolar disorder in the general population which was supported by the genetic analysis.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1192/bjp.bp.114.150870

DO - 10.1192/bjp.bp.114.150870

M3 - Journal article

C2 - 26250741

SN - 0960-5371

VL - 208

SP - 138

EP - 145

JO - The Journal of mental science

JF - The Journal of mental science

IS - 2

ER -