Abstract
BACKGROUND: No prospective studies have examined the role of C-reactive protein (CRP) in late-onset bipolar disorder.
AIMS: We tested the hypothesis that elevated levels of CRP are associated cross-sectionally and prospectively with late-onset bipolar disorder, and that such an association possibly is causal.
METHOD: We performed cross-sectional and prospective analyses with a median follow-up time of 5.9 years (interquartile range: 4.4-7.6) in 78 809 individuals from the general population, and used genetic variants influencing CRP levels to perform a Mendelian randomisation study.
RESULTS: Elevated levels of CRP were associated both cross-sectionally and prospectively with late-onset bipolar disorder. When CRP was on a continuous scale, a doubling in CRP yielded an observational odds ratio for late-onset bipolar disorder of 1.28 (1.08-1.52) with a corresponding causal odds ratio of 4.66 (0.89-24.3).
CONCLUSION: Elevated CRP is associated with increased risk of late-onset bipolar disorder in the general population which was supported by the genetic analysis.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | British Journal of Psychiatry |
| Vol/bind | 208 |
| Udgave nummer | 2 |
| Sider (fra-til) | 138-45 |
| Antal sider | 8 |
| ISSN | 0007-1250 |
| DOI | |
| Status | Udgivet - feb. 2016 |