EIF5A mediates autophagy via translation of ATG3

Lisa B. Frankel

doi:10.1080/15548627.2018.1491213

EIF5A mediates autophagy via translation of ATG3

Lisa B. Frankel^*

^*Corresponding author for this work

2 Citations (Scopus)

Abstract

The core macroautophagy/autophagy machinery consists of a large group of autophagy-related (ATG) proteins, that mediate highly controlled, step-wise execution of this conserved intracellular degradation process. Whereas ATG proteins have been intensely studied in terms of protein interactions, post-translational modifications and transcriptional regulation, the mechanisms ensuring efficient translation of ATG proteins are not well understood. In a recent study, we describe an evolutionarily conserved role for EIF5A (eukaryotic translation initiation factor 5A) in autophagy. We demonstrate that EIF5A mediates Atg8-family protein lipidation and autophagosome formation via translation of the E2-like ATG3 protein. Moreover, we identify a particular motif in ATG3 causing EIF5A-dependency for its efficient translation.

Original language	English
Journal	Autophagy
Volume	14
Issue number	7
Pages (from-to)	1288-1289
Number of pages	2
ISSN	1554-8627
DOIs	https://doi.org/10.1080/15548627.2018.1491213
Publication status	Published - 2018

Keywords

ATG3
autophagy
EIF5A
lipidation
ribosome
translation

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title = "EIF5A mediates autophagy via translation of ATG3",

abstract = "The core macroautophagy/autophagy machinery consists of a large group of autophagy-related (ATG) proteins, that mediate highly controlled, step-wise execution of this conserved intracellular degradation process. Whereas ATG proteins have been intensely studied in terms of protein interactions, post-translational modifications and transcriptional regulation, the mechanisms ensuring efficient translation of ATG proteins are not well understood. In a recent study, we describe an evolutionarily conserved role for EIF5A (eukaryotic translation initiation factor 5A) in autophagy. We demonstrate that EIF5A mediates Atg8-family protein lipidation and autophagosome formation via translation of the E2-like ATG3 protein. Moreover, we identify a particular motif in ATG3 causing EIF5A-dependency for its efficient translation.",

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AU - Frankel, Lisa B.

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AB - The core macroautophagy/autophagy machinery consists of a large group of autophagy-related (ATG) proteins, that mediate highly controlled, step-wise execution of this conserved intracellular degradation process. Whereas ATG proteins have been intensely studied in terms of protein interactions, post-translational modifications and transcriptional regulation, the mechanisms ensuring efficient translation of ATG proteins are not well understood. In a recent study, we describe an evolutionarily conserved role for EIF5A (eukaryotic translation initiation factor 5A) in autophagy. We demonstrate that EIF5A mediates Atg8-family protein lipidation and autophagosome formation via translation of the E2-like ATG3 protein. Moreover, we identify a particular motif in ATG3 causing EIF5A-dependency for its efficient translation.

KW - ATG3

KW - autophagy

KW - EIF5A

KW - lipidation

KW - ribosome

KW - translation

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DO - 10.1080/15548627.2018.1491213

M3 - Comment/debate

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SN - 1554-8627

VL - 14

SP - 1288

EP - 1289

JO - Autophagy

JF - Autophagy

IS - 7

ER -

EIF5A mediates autophagy via translation of ATG3

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Keywords

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