EIF5A mediates autophagy via translation of ATG3

Lisa B. Frankel

doi:10.1080/15548627.2018.1491213

EIF5A mediates autophagy via translation of ATG3

Lisa B. Frankel^*

^*Corresponding author af dette arbejde

2 Citationer (Scopus)

Abstract

The core macroautophagy/autophagy machinery consists of a large group of autophagy-related (ATG) proteins, that mediate highly controlled, step-wise execution of this conserved intracellular degradation process. Whereas ATG proteins have been intensely studied in terms of protein interactions, post-translational modifications and transcriptional regulation, the mechanisms ensuring efficient translation of ATG proteins are not well understood. In a recent study, we describe an evolutionarily conserved role for EIF5A (eukaryotic translation initiation factor 5A) in autophagy. We demonstrate that EIF5A mediates Atg8-family protein lipidation and autophagosome formation via translation of the E2-like ATG3 protein. Moreover, we identify a particular motif in ATG3 causing EIF5A-dependency for its efficient translation.

Originalsprog	Engelsk
Tidsskrift	Autophagy
Vol/bind	14
Udgave nummer	7
Sider (fra-til)	1288-1289
Antal sider	2
ISSN	1554-8627
DOI	https://doi.org/10.1080/15548627.2018.1491213
Status	Udgivet - 2018

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10.1080/15548627.2018.1491213

15548627.2018.1491213?needAccess=trueForlagets udgivne version, 760 KB

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abstract = "The core macroautophagy/autophagy machinery consists of a large group of autophagy-related (ATG) proteins, that mediate highly controlled, step-wise execution of this conserved intracellular degradation process. Whereas ATG proteins have been intensely studied in terms of protein interactions, post-translational modifications and transcriptional regulation, the mechanisms ensuring efficient translation of ATG proteins are not well understood. In a recent study, we describe an evolutionarily conserved role for EIF5A (eukaryotic translation initiation factor 5A) in autophagy. We demonstrate that EIF5A mediates Atg8-family protein lipidation and autophagosome formation via translation of the E2-like ATG3 protein. Moreover, we identify a particular motif in ATG3 causing EIF5A-dependency for its efficient translation.",

keywords = "ATG3, autophagy, EIF5A, lipidation, ribosome, translation",

author = "Frankel, {Lisa B.}",

year = "2018",

doi = "10.1080/15548627.2018.1491213",

language = "English",

volume = "14",

pages = "1288--1289",

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T1 - EIF5A mediates autophagy via translation of ATG3

AU - Frankel, Lisa B.

PY - 2018

Y1 - 2018

N2 - The core macroautophagy/autophagy machinery consists of a large group of autophagy-related (ATG) proteins, that mediate highly controlled, step-wise execution of this conserved intracellular degradation process. Whereas ATG proteins have been intensely studied in terms of protein interactions, post-translational modifications and transcriptional regulation, the mechanisms ensuring efficient translation of ATG proteins are not well understood. In a recent study, we describe an evolutionarily conserved role for EIF5A (eukaryotic translation initiation factor 5A) in autophagy. We demonstrate that EIF5A mediates Atg8-family protein lipidation and autophagosome formation via translation of the E2-like ATG3 protein. Moreover, we identify a particular motif in ATG3 causing EIF5A-dependency for its efficient translation.

AB - The core macroautophagy/autophagy machinery consists of a large group of autophagy-related (ATG) proteins, that mediate highly controlled, step-wise execution of this conserved intracellular degradation process. Whereas ATG proteins have been intensely studied in terms of protein interactions, post-translational modifications and transcriptional regulation, the mechanisms ensuring efficient translation of ATG proteins are not well understood. In a recent study, we describe an evolutionarily conserved role for EIF5A (eukaryotic translation initiation factor 5A) in autophagy. We demonstrate that EIF5A mediates Atg8-family protein lipidation and autophagosome formation via translation of the E2-like ATG3 protein. Moreover, we identify a particular motif in ATG3 causing EIF5A-dependency for its efficient translation.

KW - ATG3

KW - autophagy

KW - EIF5A

KW - lipidation

KW - ribosome

KW - translation

U2 - 10.1080/15548627.2018.1491213

DO - 10.1080/15548627.2018.1491213

M3 - Comment/debate

C2 - 29973124

AN - SCOPUS:85050352093

SN - 1554-8627

VL - 14

SP - 1288

EP - 1289

JO - Autophagy

JF - Autophagy

IS - 7

ER -

EIF5A mediates autophagy via translation of ATG3

Abstract

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