Effects of Long-Term Physical Activity and Diet on Skin Glycation and Achilles Tendon Structure

Joachim Nymann Hjerrild; Alexander Wobbe; Martin B Stausholm; Anne Ellegaard Larsen; Christian Ohrhammer Josefsen; Nikolaj M Malmgaard-Clausen; Flemming Dela; Michael Kjaer; S Peter Magnusson; Mette Hansen; Rene B Svensson; Christian Couppé

doi:10.3390/nu11061409

Effects of Long-Term Physical Activity and Diet on Skin Glycation and Achilles Tendon Structure

Joachim Nymann Hjerrild, Alexander Wobbe, Martin B Stausholm, Anne Ellegaard Larsen, Christian Ohrhammer Josefsen, Nikolaj M Malmgaard-Clausen, Flemming Dela, Michael Kjaer, S Peter Magnusson, Mette Hansen, Rene B Svensson, Christian Couppé

4 Citations (Scopus)

Abstract

Advanced glycation end-products (AGEs) accumulate with aging and have been associated with tissue modifications and metabolic disease. Regular exercise has several health benefits, and the purpose of this study was to investigate the effect of regular long-term exercise and diet on skin autofluorescence (SAF) as a measure of glycation and on Achilles tendon structure. In connection with the 2017 European Masters Athletics Championships Stadia, high-level male athletes (n = 194) that had regularly trained for more than 10 years were recruited, in addition to untrained controls (n = 34). SAF was non-invasively determined using an AGE Reader. Achilles tendon thickness and vascular Doppler activity were measured by ultrasonography, and diet was assessed by a questionnaire. There was no significant difference in SAF between the athletes and controls. However, greater duration of exercise was independently associated with lower SAF. Diet also had an effect, with a more "Western" diet in youth being associated with increased SAF. Furthermore, our data demonstrated that greater Achilles tendon thickness was associated with aging and training. Together, our data indicate that long-term exercise may yield a modest reduction in glycation and substantially increase Achilles tendon size, which may protect against injury.

Original language	English
Journal	Nutrients
Volume	11
Issue number	6
ISSN	2072-6643
DOIs	https://doi.org/10.3390/nu11061409
Publication status	Published - 22 Jun 2019

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title = "Effects of Long-Term Physical Activity and Diet on Skin Glycation and Achilles Tendon Structure",

abstract = "Advanced glycation end-products (AGEs) accumulate with aging and have been associated with tissue modifications and metabolic disease. Regular exercise has several health benefits, and the purpose of this study was to investigate the effect of regular long-term exercise and diet on skin autofluorescence (SAF) as a measure of glycation and on Achilles tendon structure. In connection with the 2017 European Masters Athletics Championships Stadia, high-level male athletes (n = 194) that had regularly trained for more than 10 years were recruited, in addition to untrained controls (n = 34). SAF was non-invasively determined using an AGE Reader. Achilles tendon thickness and vascular Doppler activity were measured by ultrasonography, and diet was assessed by a questionnaire. There was no significant difference in SAF between the athletes and controls. However, greater duration of exercise was independently associated with lower SAF. Diet also had an effect, with a more {"}Western{"} diet in youth being associated with increased SAF. Furthermore, our data demonstrated that greater Achilles tendon thickness was associated with aging and training. Together, our data indicate that long-term exercise may yield a modest reduction in glycation and substantially increase Achilles tendon size, which may protect against injury.",

author = "Hjerrild, {Joachim Nymann} and Alexander Wobbe and Stausholm, {Martin B} and Larsen, {Anne Ellegaard} and Josefsen, {Christian Ohrhammer} and Malmgaard-Clausen, {Nikolaj M} and Flemming Dela and Michael Kjaer and Magnusson, {S Peter} and Mette Hansen and Svensson, {Rene B} and Christian Coupp{\'e}",

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doi = "10.3390/nu11061409",

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T1 - Effects of Long-Term Physical Activity and Diet on Skin Glycation and Achilles Tendon Structure

AU - Hjerrild, Joachim Nymann

AU - Wobbe, Alexander

AU - Stausholm, Martin B

AU - Larsen, Anne Ellegaard

AU - Josefsen, Christian Ohrhammer

AU - Malmgaard-Clausen, Nikolaj M

AU - Dela, Flemming

AU - Kjaer, Michael

AU - Magnusson, S Peter

AU - Hansen, Mette

AU - Svensson, Rene B

AU - Couppé, Christian

PY - 2019/6/22

Y1 - 2019/6/22

N2 - Advanced glycation end-products (AGEs) accumulate with aging and have been associated with tissue modifications and metabolic disease. Regular exercise has several health benefits, and the purpose of this study was to investigate the effect of regular long-term exercise and diet on skin autofluorescence (SAF) as a measure of glycation and on Achilles tendon structure. In connection with the 2017 European Masters Athletics Championships Stadia, high-level male athletes (n = 194) that had regularly trained for more than 10 years were recruited, in addition to untrained controls (n = 34). SAF was non-invasively determined using an AGE Reader. Achilles tendon thickness and vascular Doppler activity were measured by ultrasonography, and diet was assessed by a questionnaire. There was no significant difference in SAF between the athletes and controls. However, greater duration of exercise was independently associated with lower SAF. Diet also had an effect, with a more "Western" diet in youth being associated with increased SAF. Furthermore, our data demonstrated that greater Achilles tendon thickness was associated with aging and training. Together, our data indicate that long-term exercise may yield a modest reduction in glycation and substantially increase Achilles tendon size, which may protect against injury.

AB - Advanced glycation end-products (AGEs) accumulate with aging and have been associated with tissue modifications and metabolic disease. Regular exercise has several health benefits, and the purpose of this study was to investigate the effect of regular long-term exercise and diet on skin autofluorescence (SAF) as a measure of glycation and on Achilles tendon structure. In connection with the 2017 European Masters Athletics Championships Stadia, high-level male athletes (n = 194) that had regularly trained for more than 10 years were recruited, in addition to untrained controls (n = 34). SAF was non-invasively determined using an AGE Reader. Achilles tendon thickness and vascular Doppler activity were measured by ultrasonography, and diet was assessed by a questionnaire. There was no significant difference in SAF between the athletes and controls. However, greater duration of exercise was independently associated with lower SAF. Diet also had an effect, with a more "Western" diet in youth being associated with increased SAF. Furthermore, our data demonstrated that greater Achilles tendon thickness was associated with aging and training. Together, our data indicate that long-term exercise may yield a modest reduction in glycation and substantially increase Achilles tendon size, which may protect against injury.

U2 - 10.3390/nu11061409

DO - 10.3390/nu11061409

M3 - Journal article

C2 - 31234508

SN - 2072-6643

VL - 11

JO - Nutrients

JF - Nutrients

IS - 6

ER -

Effects of Long-Term Physical Activity and Diet on Skin Glycation and Achilles Tendon Structure

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