Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro

Arne Schousboe; Helle S. Waagepetersen; Renata Leke; Lasse K Bak

doi:10.1007/s11011-014-9513-8

Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro

Arne Schousboe, Helle S. Waagepetersen, Renata Leke, Lasse K Bak

13 Citationer (Scopus)

Abstract

The literature related to the effects of elevated plasma ammonia levels on brain energy metabolism is abundant, but heterogeneous in terms of the conclusions. Thus, some studies claim that ammonia has a direct, inhibitory effect on energy metabolism whereas others find no such correlation. In this review, we discuss both recent and older literature related to this controversial topic. We find that it has been consistently reported that hepatic encephalopathy and concomitant hyperammonemia lead to reduced cerebral oxygen consumption. However, this may not be directly linked to an effect of ammonia but related to the fact that hepatic encephalopathy is always associated with reduced brain activity, a condition clearly characterized by a decreased CMRO2. Whether this may be related to changes in GABAergic function remains to be elucidated.

Originalsprog	Engelsk
Tidsskrift	Metabolic Brain Disease
Vol/bind	29
Udgave nummer	4
Sider (fra-til)	913-917
Antal sider	5
ISSN	0885-7490
DOI	https://doi.org/10.1007/s11011-014-9513-8
Status	Udgivet - 13 nov. 2014

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10.1007/s11011-014-9513-8

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abstract = "The literature related to the effects of elevated plasma ammonia levels on brain energy metabolism is abundant, but heterogeneous in terms of the conclusions. Thus, some studies claim that ammonia has a direct, inhibitory effect on energy metabolism whereas others find no such correlation. In this review, we discuss both recent and older literature related to this controversial topic. We find that it has been consistently reported that hepatic encephalopathy and concomitant hyperammonemia lead to reduced cerebral oxygen consumption. However, this may not be directly linked to an effect of ammonia but related to the fact that hepatic encephalopathy is always associated with reduced brain activity, a condition clearly characterized by a decreased CMRO2. Whether this may be related to changes in GABAergic function remains to be elucidated.",

author = "Arne Schousboe and Waagepetersen, {Helle S.} and Renata Leke and Bak, {Lasse K}",

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T1 - Effects of hyperammonemia on brain energy metabolism

T2 - controversial findings in vivo and in vitro

AU - Schousboe, Arne

AU - Waagepetersen, Helle S.

AU - Leke, Renata

AU - Bak, Lasse K

PY - 2014/11/13

Y1 - 2014/11/13

N2 - The literature related to the effects of elevated plasma ammonia levels on brain energy metabolism is abundant, but heterogeneous in terms of the conclusions. Thus, some studies claim that ammonia has a direct, inhibitory effect on energy metabolism whereas others find no such correlation. In this review, we discuss both recent and older literature related to this controversial topic. We find that it has been consistently reported that hepatic encephalopathy and concomitant hyperammonemia lead to reduced cerebral oxygen consumption. However, this may not be directly linked to an effect of ammonia but related to the fact that hepatic encephalopathy is always associated with reduced brain activity, a condition clearly characterized by a decreased CMRO2. Whether this may be related to changes in GABAergic function remains to be elucidated.

AB - The literature related to the effects of elevated plasma ammonia levels on brain energy metabolism is abundant, but heterogeneous in terms of the conclusions. Thus, some studies claim that ammonia has a direct, inhibitory effect on energy metabolism whereas others find no such correlation. In this review, we discuss both recent and older literature related to this controversial topic. We find that it has been consistently reported that hepatic encephalopathy and concomitant hyperammonemia lead to reduced cerebral oxygen consumption. However, this may not be directly linked to an effect of ammonia but related to the fact that hepatic encephalopathy is always associated with reduced brain activity, a condition clearly characterized by a decreased CMRO2. Whether this may be related to changes in GABAergic function remains to be elucidated.

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JO - Metabolic Brain Disease

JF - Metabolic Brain Disease

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ER -

Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro

Abstract

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