Effects of growth hormone on glucose and fat metabolism in human subjects

Jens O L Jørgensen; Louise Møller; Morten Brøgger Krag; Nils Billestrup; Jens Kristian S. Christiansen

doi:10.1016/j.ecl.2006.11.005

Effects of growth hormone on glucose and fat metabolism in human subjects

Jens O L Jørgensen, Louise Møller, Morten Brøgger Krag, Nils Billestrup, Jens Kristian S. Christiansen

47 Citations (Scopus)

Abstract

This article focuses on in vivo data from tests performed in normal subjects and in patients who had abnormal growth hormone (GH) status. Experimental data in human subjects demonstrate that GH acutely inhibits glucose disposal in skeletal muscle. At the same time GH stimulates the turnover and oxidation of free fatty acid (FFA), and experimental evidence suggests a causal link between elevated FFA levels and insulin resistance in skeletal muscle. Observational data in GH-deficient adults do not indicate that GH replacement is associated with significant impairment of glucose tolerance, but it is recommended that overdosing be avoided and glycemic control be monitored.

Original language	English
Journal	Endocrinology & Metabolism Clinics of North America
Volume	36
Issue number	1
Pages (from-to)	75-87
Number of pages	13
ISSN	0889-8529
DOIs	https://doi.org/10.1016/j.ecl.2006.11.005
Publication status	Published - 1 Mar 2007

Keywords

Fasting
Glucose
Growth Hormone
Humans
Insulin Resistance
Lipid Metabolism
Models, Biological
Research Subjects

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10.1016/j.ecl.2006.11.005

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abstract = "This article focuses on in vivo data from tests performed in normal subjects and in patients who had abnormal growth hormone (GH) status. Experimental data in human subjects demonstrate that GH acutely inhibits glucose disposal in skeletal muscle. At the same time GH stimulates the turnover and oxidation of free fatty acid (FFA), and experimental evidence suggests a causal link between elevated FFA levels and insulin resistance in skeletal muscle. Observational data in GH-deficient adults do not indicate that GH replacement is associated with significant impairment of glucose tolerance, but it is recommended that overdosing be avoided and glycemic control be monitored.",

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AU - Krag, Morten Brøgger

AU - Billestrup, Nils

AU - Christiansen, Jens Kristian S.

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KW - Insulin Resistance

KW - Lipid Metabolism

KW - Models, Biological

KW - Research Subjects

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JO - Endocrinology & Metabolism Clinics of North America

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Effects of growth hormone on glucose and fat metabolism in human subjects

Abstract

Keywords

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