Effects of growth hormone on glucose and fat metabolism in human subjects

Jens O L Jørgensen; Louise Møller; Morten Brøgger Krag; Nils Billestrup; Jens Kristian S. Christiansen

doi:10.1016/j.ecl.2006.11.005

Effects of growth hormone on glucose and fat metabolism in human subjects

Jens O L Jørgensen, Louise Møller, Morten Brøgger Krag, Nils Billestrup, Jens Kristian S. Christiansen

47 Citationer (Scopus)

Abstract

This article focuses on in vivo data from tests performed in normal subjects and in patients who had abnormal growth hormone (GH) status. Experimental data in human subjects demonstrate that GH acutely inhibits glucose disposal in skeletal muscle. At the same time GH stimulates the turnover and oxidation of free fatty acid (FFA), and experimental evidence suggests a causal link between elevated FFA levels and insulin resistance in skeletal muscle. Observational data in GH-deficient adults do not indicate that GH replacement is associated with significant impairment of glucose tolerance, but it is recommended that overdosing be avoided and glycemic control be monitored.

Originalsprog	Engelsk
Tidsskrift	Endocrinology & Metabolism Clinics of North America
Vol/bind	36
Udgave nummer	1
Sider (fra-til)	75-87
Antal sider	13
ISSN	0889-8529
DOI	https://doi.org/10.1016/j.ecl.2006.11.005
Status	Udgivet - 1 mar. 2007

Adgang til dokumentet

10.1016/j.ecl.2006.11.005

Citationsformater

@article{1dafb6c3303748f998ca3dc50c4eb91a,

title = "Effects of growth hormone on glucose and fat metabolism in human subjects",

abstract = "This article focuses on in vivo data from tests performed in normal subjects and in patients who had abnormal growth hormone (GH) status. Experimental data in human subjects demonstrate that GH acutely inhibits glucose disposal in skeletal muscle. At the same time GH stimulates the turnover and oxidation of free fatty acid (FFA), and experimental evidence suggests a causal link between elevated FFA levels and insulin resistance in skeletal muscle. Observational data in GH-deficient adults do not indicate that GH replacement is associated with significant impairment of glucose tolerance, but it is recommended that overdosing be avoided and glycemic control be monitored.",

keywords = "Fasting, Glucose, Growth Hormone, Humans, Insulin Resistance, Lipid Metabolism, Models, Biological, Research Subjects",

author = "J{\o}rgensen, {Jens O L} and Louise M{\o}ller and Krag, {Morten Br{\o}gger} and Nils Billestrup and Christiansen, {Jens Kristian S.}",

year = "2007",

month = mar,

day = "1",

doi = "10.1016/j.ecl.2006.11.005",

language = "English",

volume = "36",

pages = "75--87",

journal = "Endocrinology & Metabolism Clinics of North America",

issn = "0889-8529",

publisher = "W.B.Saunders Co.",

number = "1",

}

TY - JOUR

T1 - Effects of growth hormone on glucose and fat metabolism in human subjects

AU - Jørgensen, Jens O L

AU - Møller, Louise

AU - Krag, Morten Brøgger

AU - Billestrup, Nils

AU - Christiansen, Jens Kristian S.

PY - 2007/3/1

Y1 - 2007/3/1

N2 - This article focuses on in vivo data from tests performed in normal subjects and in patients who had abnormal growth hormone (GH) status. Experimental data in human subjects demonstrate that GH acutely inhibits glucose disposal in skeletal muscle. At the same time GH stimulates the turnover and oxidation of free fatty acid (FFA), and experimental evidence suggests a causal link between elevated FFA levels and insulin resistance in skeletal muscle. Observational data in GH-deficient adults do not indicate that GH replacement is associated with significant impairment of glucose tolerance, but it is recommended that overdosing be avoided and glycemic control be monitored.

AB - This article focuses on in vivo data from tests performed in normal subjects and in patients who had abnormal growth hormone (GH) status. Experimental data in human subjects demonstrate that GH acutely inhibits glucose disposal in skeletal muscle. At the same time GH stimulates the turnover and oxidation of free fatty acid (FFA), and experimental evidence suggests a causal link between elevated FFA levels and insulin resistance in skeletal muscle. Observational data in GH-deficient adults do not indicate that GH replacement is associated with significant impairment of glucose tolerance, but it is recommended that overdosing be avoided and glycemic control be monitored.

KW - Fasting

KW - Glucose

KW - Growth Hormone

KW - Humans

KW - Insulin Resistance

KW - Lipid Metabolism

KW - Models, Biological

KW - Research Subjects

U2 - 10.1016/j.ecl.2006.11.005

DO - 10.1016/j.ecl.2006.11.005

M3 - Journal article

C2 - 17336735

SN - 0889-8529

VL - 36

SP - 75

EP - 87

JO - Endocrinology & Metabolism Clinics of North America

JF - Endocrinology & Metabolism Clinics of North America

IS - 1

ER -

Effects of growth hormone on glucose and fat metabolism in human subjects

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater