Abstract
The purpose is to investigate the effects of chondroitin sulfate and glucosamine on adult patients with Kaschin-Beck disease (KBD). A total of 80 patients, aged over 40 years, were randomized into two groups receiving either 1,600 mg oral mixture of chondroitin sulfate and glucosamine or placebo twice daily for 8 months. Posteroanterior radiographs of bilateral knee in full extension were taken at enrollment and after 8 months. Mean joint-space width of the assigned six points on the tibiofemoral joint compartment was measured by a graduated magnifying lens. The mean joint space decreased significantly in the placebo group (4.3±1.09 versus 4.1±1.07 mm, P<0.0001) after 8 months and was unchanged in the experimental group (P=0.51). There was no statistical significance in the mean joint space between two groups at baseline and follow-up (P=0.65 and P=0.84, respectively). But the overall mean change in joint space was significant between the two groups (P<0.0001). Knee joint space of the experimental group narrowed slowly compared to the control group. Therefore, chondroitin sulfate and glucosamine might play a protective role in preserving articular cartilage and provide evidence for therapeutic drugs in adult patients with KBD.
| Original language | English |
|---|---|
| Journal | Clinical Rheumatology |
| Volume | 29 |
| Issue number | 4 |
| Pages (from-to) | 357-62 |
| Number of pages | 6 |
| ISSN | 0770-3198 |
| DOIs | |
| Publication status | Published - 1 Apr 2010 |
Keywords
- Adult
- Chondroitin Sulfates
- Dietary Supplements
- Double-Blind Method
- Drug Combinations
- Female
- Glucosamine
- Humans
- Male
- Middle Aged
- Osteoarthritis
- T-2 Toxin