Abstract
The purpose is to investigate the effects of chondroitin sulfate and glucosamine on adult patients with Kaschin-Beck disease (KBD). A total of 80 patients, aged over 40 years, were randomized into two groups receiving either 1,600 mg oral mixture of chondroitin sulfate and glucosamine or placebo twice daily for 8 months. Posteroanterior radiographs of bilateral knee in full extension were taken at enrollment and after 8 months. Mean joint-space width of the assigned six points on the tibiofemoral joint compartment was measured by a graduated magnifying lens. The mean joint space decreased significantly in the placebo group (4.3±1.09 versus 4.1±1.07 mm, P<0.0001) after 8 months and was unchanged in the experimental group (P=0.51). There was no statistical significance in the mean joint space between two groups at baseline and follow-up (P=0.65 and P=0.84, respectively). But the overall mean change in joint space was significant between the two groups (P<0.0001). Knee joint space of the experimental group narrowed slowly compared to the control group. Therefore, chondroitin sulfate and glucosamine might play a protective role in preserving articular cartilage and provide evidence for therapeutic drugs in adult patients with KBD.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Clinical Rheumatology |
| Vol/bind | 29 |
| Udgave nummer | 4 |
| Sider (fra-til) | 357-62 |
| Antal sider | 6 |
| ISSN | 0770-3198 |
| DOI | |
| Status | Udgivet - 1 apr. 2010 |