Effects of casein, whey and soy proteins on volumetric bone density and bone strength in immunocompromised piglets

Alicja Zofia Budek; Charlotte Bjørnvad; Christian Mølgaard; Susanne Gjedsted Bügel; Mogens Vestergaard; Pasi Pulkkinen; Kim Fleischer Michaelsen; Per Torp Sangild

doi:10.1016/j.eclnm.2007.03.003

Effects of casein, whey and soy proteins on volumetric bone density and bone strength in immunocompromised piglets

Alicja Zofia Budek, Charlotte Bjørnvad, Christian Mølgaard, Susanne Gjedsted Bügel, Mogens Vestergaard, Pasi Pulkkinen, Kim Fleischer Michaelsen, Per Torp Sangild

6 Citations (Scopus)

Abstract

Summary:Background and aims: Bone-promoting effect of different proteins in early life, under immunocompromised conditions, is unknown. We investigated effects of milk- and plantderived proteins on bone development in immunocompromised piglets.
Methods: Newborn, colostrum-deprived piglets were assigned to a formula based on either casein (n=11), whey (n=11) or soy (n=10) as the protein source (each 55 g/L), and equal amounts of fat, carbohydrates, calcium and phosphorus.
Results & Conclusion: Despite efforts to sustain immuno-protection (sow serum and antibiotic injections), some piglets became sick and were early euthanised. After 6 days, bone density (peripheral quantitative computed tomography), bone mechanical strength (three-point bending test) and serum insulin-like growth factor-I (sIGF-I) (immunoassay) were measured in the surviving piglets (casein n=5, whey n=9, soy n=5).

Original language	English
Journal	e - S P E N
Volume	2
Issue number	3
Pages (from-to)	57-62
Number of pages	6
ISSN	1751-4991
DOIs	https://doi.org/10.1016/j.eclnm.2007.03.003
Publication status	Published - 2007

Keywords

Former LIFE faculty
BMD;
Dietary protein
Immunocompromised piglets
pQCT

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10.1016/j.eclnm.2007.03.003

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@article{5567db60a1c211ddb6ae000ea68e967b,

title = "Effects of casein, whey and soy proteins on volumetric bone density and bone strength in immunocompromised piglets",

abstract = "Summary:Background and aims: Bone-promoting effect of different proteins in early life, under immunocompromised conditions, is unknown. We investigated effects of milk- and plantderived proteins on bone development in immunocompromised piglets.Methods: Newborn, colostrum-deprived piglets were assigned to a formula based on either casein (n=11), whey (n=11) or soy (n=10) as the protein source (each 55 g/L), and equal amounts of fat, carbohydrates, calcium and phosphorus.Results & Conclusion: Despite efforts to sustain immuno-protection (sow serum and antibiotic injections), some piglets became sick and were early euthanised. After 6 days, bone density (peripheral quantitative computed tomography), bone mechanical strength (three-point bending test) and serum insulin-like growth factor-I (sIGF-I) (immunoassay) were measured in the surviving piglets (casein n=5, whey n=9, soy n=5). ",

keywords = "Former LIFE faculty, BMD;, Dietary protein, Immunocompromised piglets, pQCT",

author = "Budek, {Alicja Zofia} and Charlotte Bj{\o}rnvad and Christian M{\o}lgaard and B{\"u}gel, {Susanne Gjedsted} and Mogens Vestergaard and Pasi Pulkkinen and Michaelsen, {Kim Fleischer} and Sangild, {Per Torp}",

year = "2007",

doi = "10.1016/j.eclnm.2007.03.003",

language = "English",

volume = "2",

pages = "57--62",

journal = "Clinical Nutrition ESPEN",

issn = "2405-4577",

publisher = "Elsevier",

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TY - JOUR

T1 - Effects of casein, whey and soy proteins on volumetric bone density and bone strength in immunocompromised piglets

AU - Budek, Alicja Zofia

AU - Bjørnvad, Charlotte

AU - Mølgaard, Christian

AU - Bügel, Susanne Gjedsted

AU - Vestergaard, Mogens

AU - Pulkkinen, Pasi

AU - Michaelsen, Kim Fleischer

AU - Sangild, Per Torp

PY - 2007

Y1 - 2007

N2 - Summary:Background and aims: Bone-promoting effect of different proteins in early life, under immunocompromised conditions, is unknown. We investigated effects of milk- and plantderived proteins on bone development in immunocompromised piglets.Methods: Newborn, colostrum-deprived piglets were assigned to a formula based on either casein (n=11), whey (n=11) or soy (n=10) as the protein source (each 55 g/L), and equal amounts of fat, carbohydrates, calcium and phosphorus.Results & Conclusion: Despite efforts to sustain immuno-protection (sow serum and antibiotic injections), some piglets became sick and were early euthanised. After 6 days, bone density (peripheral quantitative computed tomography), bone mechanical strength (three-point bending test) and serum insulin-like growth factor-I (sIGF-I) (immunoassay) were measured in the surviving piglets (casein n=5, whey n=9, soy n=5).

AB - Summary:Background and aims: Bone-promoting effect of different proteins in early life, under immunocompromised conditions, is unknown. We investigated effects of milk- and plantderived proteins on bone development in immunocompromised piglets.Methods: Newborn, colostrum-deprived piglets were assigned to a formula based on either casein (n=11), whey (n=11) or soy (n=10) as the protein source (each 55 g/L), and equal amounts of fat, carbohydrates, calcium and phosphorus.Results & Conclusion: Despite efforts to sustain immuno-protection (sow serum and antibiotic injections), some piglets became sick and were early euthanised. After 6 days, bone density (peripheral quantitative computed tomography), bone mechanical strength (three-point bending test) and serum insulin-like growth factor-I (sIGF-I) (immunoassay) were measured in the surviving piglets (casein n=5, whey n=9, soy n=5).

KW - Former LIFE faculty

KW - BMD;

KW - Dietary protein

KW - Immunocompromised piglets

KW - pQCT

U2 - 10.1016/j.eclnm.2007.03.003

DO - 10.1016/j.eclnm.2007.03.003

M3 - Journal article

SN - 2405-4577

VL - 2

SP - 57

EP - 62

JO - Clinical Nutrition ESPEN

JF - Clinical Nutrition ESPEN

IS - 3

ER -

Effects of casein, whey and soy proteins on volumetric bone density and bone strength in immunocompromised piglets

Abstract

Keywords

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