Effects and side effects of plasmonic photothermal therapy in brain tissue

Yue He, Kristoffer Laugesen, Dana Kamp, Salik A. Sultan, Lene B. Oddershede, Liselotte Jauffred*

*Corresponding author for this work
4 Citations (Scopus)
9 Downloads (Pure)

Abstract

Background: Heat generated from plasmonic nanoparticles can be utilized in plasmonic photothermal therapy. A combination of near-infrared laser and plasmonic nanoparticles is compelling for the treatment of brain cancer, due to the efficient light-to-heat conversion and bio-compatibility. However, one of the challenges of plasmonic photothermal therapy is to minimize the damage of the surrounding brain tissue. The adjacent tissue can be damaged as a result of either absorption of laser light, thermal conductivity, nanoparticles diffusing from the tumor, or a combination hereof. Hence, we still lack the full understanding of the light-tissue interaction and, in particular, the thermal response. Results: We tested the temperature change in three different porcine cerebral tissues, i.e., the stem, the cerebrum, and the cerebellum, under laser treatment. We find that the different tissues have differential optical and thermal properties and confirm the enhancement of heating from adding plasmonic nanoparticles. Furthermore, we measure the loss of laser intensity through the different cerebral tissues and stress the importance of correct analysis of the local environment of a brain tumor. Conclusions: Our results stress the conclusion that a personalized analysis of the local environment is needed to balance the effect and side effects prior to plasmonic photothermal therapy.

Original languageEnglish
Article numberUNSP 8
JournalCancer Nanotechnology
Volume10
Issue number1
Number of pages11
ISSN1868-6958
DOIs
Publication statusPublished - 24 Oct 2019

Keywords

  • Plasmonic nanoparticle
  • Photothermal therapy
  • Brain cancer

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