Effects and side effects of plasmonic photothermal therapy in brain tissue

TY - JOUR

T1 - Effects and side effects of plasmonic photothermal therapy in brain tissue

AU - He, Yue

AU - Laugesen, Kristoffer

AU - Kamp, Dana

AU - Sultan, Salik A.

AU - Oddershede, Lene B.

AU - Jauffred, Liselotte

PY - 2019/10/24

Y1 - 2019/10/24

N2 - Background: Heat generated from plasmonic nanoparticles can be utilized in plasmonic photothermal therapy. A combination of near-infrared laser and plasmonic nanoparticles is compelling for the treatment of brain cancer, due to the efficient light-to-heat conversion and bio-compatibility. However, one of the challenges of plasmonic photothermal therapy is to minimize the damage of the surrounding brain tissue. The adjacent tissue can be damaged as a result of either absorption of laser light, thermal conductivity, nanoparticles diffusing from the tumor, or a combination hereof. Hence, we still lack the full understanding of the light-tissue interaction and, in particular, the thermal response. Results: We tested the temperature change in three different porcine cerebral tissues, i.e., the stem, the cerebrum, and the cerebellum, under laser treatment. We find that the different tissues have differential optical and thermal properties and confirm the enhancement of heating from adding plasmonic nanoparticles. Furthermore, we measure the loss of laser intensity through the different cerebral tissues and stress the importance of correct analysis of the local environment of a brain tumor. Conclusions: Our results stress the conclusion that a personalized analysis of the local environment is needed to balance the effect and side effects prior to plasmonic photothermal therapy.

AB - Background: Heat generated from plasmonic nanoparticles can be utilized in plasmonic photothermal therapy. A combination of near-infrared laser and plasmonic nanoparticles is compelling for the treatment of brain cancer, due to the efficient light-to-heat conversion and bio-compatibility. However, one of the challenges of plasmonic photothermal therapy is to minimize the damage of the surrounding brain tissue. The adjacent tissue can be damaged as a result of either absorption of laser light, thermal conductivity, nanoparticles diffusing from the tumor, or a combination hereof. Hence, we still lack the full understanding of the light-tissue interaction and, in particular, the thermal response. Results: We tested the temperature change in three different porcine cerebral tissues, i.e., the stem, the cerebrum, and the cerebellum, under laser treatment. We find that the different tissues have differential optical and thermal properties and confirm the enhancement of heating from adding plasmonic nanoparticles. Furthermore, we measure the loss of laser intensity through the different cerebral tissues and stress the importance of correct analysis of the local environment of a brain tumor. Conclusions: Our results stress the conclusion that a personalized analysis of the local environment is needed to balance the effect and side effects prior to plasmonic photothermal therapy.

KW - Plasmonic nanoparticle

KW - Photothermal therapy

KW - Brain cancer

U2 - 10.1186/s12645-019-0053-0

DO - 10.1186/s12645-019-0053-0

M3 - Journal article

SN - 1868-6958

VL - 10

JO - Cancer Nanotechnology

JF - Cancer Nanotechnology

IS - 1

M1 - UNSP 8

ER -