Effect of tumor necrosis factor-alpha infusion on the incretin effect in healthy volunteers

Signe Tellerup Nielsen; Louise Lehrskov-Schmidt; Rikke Krogh-Madsen; Thomas Solomon; Lars Lehrskov-Schmidt; Jens Juul Holst; Kirsten Møller

doi:10.1002/dmrr.2441

Effect of tumor necrosis factor-alpha infusion on the incretin effect in healthy volunteers

Signe Tellerup Nielsen, Louise Lehrskov-Schmidt, Rikke Krogh-Madsen, Thomas Solomon, Lars Lehrskov-Schmidt, Jens Juul Holst, Kirsten Møller

19 Citations (Scopus)

Abstract

Type 2 diabetes mellitus (T2DM) is associated with peripheral insulin resistance, impaired incretin effect, and increased plasma levels of tumor necrosis factor-alpha (TNF-α). Whereas TNF-α infusion at a dose that induces systemic inflammation in healthy volunteers has been demonstrated to induce peripheral insulin resistance, the influence of this cytokine on the incretin effect is unknown.

Original language	English
Journal	Diabetes - Metabolism: Research and Reviews (Online)
Volume	29
Issue number	8
Pages (from-to)	655-663
Number of pages	9
ISSN	1520-7560
DOIs	https://doi.org/10.1002/dmrr.2441
Publication status	Published - 31 Jul 2013

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10.1002/dmrr.2441

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abstract = "Type 2 diabetes mellitus (T2DM) is associated with peripheral insulin resistance, impaired incretin effect, and increased plasma levels of tumor necrosis factor-alpha (TNF-α). Whereas TNF-α infusion at a dose that induces systemic inflammation in healthy volunteers has been demonstrated to induce peripheral insulin resistance, the influence of this cytokine on the incretin effect is unknown.",

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AU - Nielsen, Signe Tellerup

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AU - Krogh-Madsen, Rikke

AU - Solomon, Thomas

AU - Lehrskov-Schmidt, Lars

AU - Holst, Jens Juul

AU - Møller, Kirsten

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AB - Type 2 diabetes mellitus (T2DM) is associated with peripheral insulin resistance, impaired incretin effect, and increased plasma levels of tumor necrosis factor-alpha (TNF-α). Whereas TNF-α infusion at a dose that induces systemic inflammation in healthy volunteers has been demonstrated to induce peripheral insulin resistance, the influence of this cytokine on the incretin effect is unknown.

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DO - 10.1002/dmrr.2441

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JO - Diabetes/Metabolism Research and Reviews

JF - Diabetes/Metabolism Research and Reviews

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Effect of tumor necrosis factor-alpha infusion on the incretin effect in healthy volunteers

Abstract

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