Effect of praziquantel on human lymphocyte proliferation in vitro

Niels Odum; T G Theander; I C Bygbjerg

Effect of praziquantel on human lymphocyte proliferation in vitro

3 Citations (Scopus)

Abstract

The antischistosomal drugs tartar emetic and niridazole exert immunosuppression both in vitro and in vivo. In the present study the influence of praziquantel (Biltricide), a potent schistosomicidal drug, on human lymphocyte proliferation in vitro was investigated. Praziquantel 80 micrograms/ml significantly reduced thymidine incorporation by human blood mononuclear cells stimulated with mitogens and antigens, whereas no effect could be detected in concentrations below 40 micrograms/ml. Thus, praziquantel, in concentrations as high as 30 times the peak serum concentration during therapy, has no suppressive effect on human lymphocyte proliferation in vitro.

Original language	English
Journal	European Journal of Clinical Pharmacology
Volume	27
Issue number	3
Pages (from-to)	311-3
Number of pages	2
ISSN	0031-6970
Publication status	Published - 1984

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@article{1d81e9a0a0de11dd86a6000ea68e967b,

title = "Effect of praziquantel on human lymphocyte proliferation in vitro",

abstract = "The antischistosomal drugs tartar emetic and niridazole exert immunosuppression both in vitro and in vivo. In the present study the influence of praziquantel (Biltricide), a potent schistosomicidal drug, on human lymphocyte proliferation in vitro was investigated. Praziquantel 80 micrograms/ml significantly reduced thymidine incorporation by human blood mononuclear cells stimulated with mitogens and antigens, whereas no effect could be detected in concentrations below 40 micrograms/ml. Thus, praziquantel, in concentrations as high as 30 times the peak serum concentration during therapy, has no suppressive effect on human lymphocyte proliferation in vitro.",

author = "Niels Odum and Theander, {T G} and Bygbjerg, {I C}",

note = "Keywords: Adult; Dose-Response Relationship, Drug; Female; Humans; Isoquinolines; Lymphocyte Activation; Male; Praziquantel",

year = "1984",

language = "English",

volume = "27",

pages = "311--3",

journal = "European Journal of Clinical Pharmacology",

issn = "0031-6970",

publisher = "Springer",

number = "3",

}

TY - JOUR

T1 - Effect of praziquantel on human lymphocyte proliferation in vitro

AU - Odum, Niels

AU - Theander, T G

AU - Bygbjerg, I C

N1 - Keywords: Adult; Dose-Response Relationship, Drug; Female; Humans; Isoquinolines; Lymphocyte Activation; Male; Praziquantel

PY - 1984

Y1 - 1984

N2 - The antischistosomal drugs tartar emetic and niridazole exert immunosuppression both in vitro and in vivo. In the present study the influence of praziquantel (Biltricide), a potent schistosomicidal drug, on human lymphocyte proliferation in vitro was investigated. Praziquantel 80 micrograms/ml significantly reduced thymidine incorporation by human blood mononuclear cells stimulated with mitogens and antigens, whereas no effect could be detected in concentrations below 40 micrograms/ml. Thus, praziquantel, in concentrations as high as 30 times the peak serum concentration during therapy, has no suppressive effect on human lymphocyte proliferation in vitro.

AB - The antischistosomal drugs tartar emetic and niridazole exert immunosuppression both in vitro and in vivo. In the present study the influence of praziquantel (Biltricide), a potent schistosomicidal drug, on human lymphocyte proliferation in vitro was investigated. Praziquantel 80 micrograms/ml significantly reduced thymidine incorporation by human blood mononuclear cells stimulated with mitogens and antigens, whereas no effect could be detected in concentrations below 40 micrograms/ml. Thus, praziquantel, in concentrations as high as 30 times the peak serum concentration during therapy, has no suppressive effect on human lymphocyte proliferation in vitro.

M3 - Journal article

C2 - 6510458

SN - 0031-6970

VL - 27

SP - 311

EP - 313

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

IS - 3

ER -

Effect of praziquantel on human lymphocyte proliferation in vitro

Abstract

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