TY - JOUR
T1 - Effect of praziquantel on human lymphocyte proliferation in vitro
AU - Odum, Niels
AU - Theander, T G
AU - Bygbjerg, I C
N1 - Keywords: Adult; Dose-Response Relationship, Drug; Female; Humans; Isoquinolines; Lymphocyte Activation; Male; Praziquantel
PY - 1984
Y1 - 1984
N2 - The antischistosomal drugs tartar emetic and niridazole exert immunosuppression both in vitro and in vivo. In the present study the influence of praziquantel (Biltricide), a potent schistosomicidal drug, on human lymphocyte proliferation in vitro was investigated. Praziquantel 80 micrograms/ml significantly reduced thymidine incorporation by human blood mononuclear cells stimulated with mitogens and antigens, whereas no effect could be detected in concentrations below 40 micrograms/ml. Thus, praziquantel, in concentrations as high as 30 times the peak serum concentration during therapy, has no suppressive effect on human lymphocyte proliferation in vitro.
AB - The antischistosomal drugs tartar emetic and niridazole exert immunosuppression both in vitro and in vivo. In the present study the influence of praziquantel (Biltricide), a potent schistosomicidal drug, on human lymphocyte proliferation in vitro was investigated. Praziquantel 80 micrograms/ml significantly reduced thymidine incorporation by human blood mononuclear cells stimulated with mitogens and antigens, whereas no effect could be detected in concentrations below 40 micrograms/ml. Thus, praziquantel, in concentrations as high as 30 times the peak serum concentration during therapy, has no suppressive effect on human lymphocyte proliferation in vitro.
M3 - Journal article
C2 - 6510458
SN - 0031-6970
VL - 27
SP - 311
EP - 313
JO - European Journal of Clinical Pharmacology
JF - European Journal of Clinical Pharmacology
IS - 3
ER -