Abstract
Local hemostatics for osseous tissue should preferably be absorbable and biocompatible and should not inhibit osteogenesis. The tissue response and effect on demineralized bone-induced heterotopic osteogenesis in the abdominal muscle of 120 male Wistar rats by different local hemostatics were evaluated by light microscopy and 85Sr uptake analyses. Non-absorbable bone wax of 88% beeswax and absorbable bovine fibrin-collagen paste both significantly inhibited osteoinduction, whereas a bioerodible polyorthoester drug delivery system with or without 4% gentamicin did not. Bone wax was not absorbed and induced a chronic foreign body reaction. Fibrin-collagen paste induced less inflammation with numerous monocytes and macrophages with engulfed material. Bioerodible polyorthoester caused a very moderate tissue reaction and was mostly resorbed at week 4.
| Original language | English |
|---|---|
| Journal | Journal of Biomedical Materials Research |
| Volume | 26 |
| Issue number | 6 |
| Pages (from-to) | 791-800 |
| Number of pages | 10 |
| ISSN | 0021-9304 |
| DOIs | |
| Publication status | Published - 1 Jun 1992 |
Keywords
- Absorption
- Animals
- Biocompatible Materials
- Bone and Bones
- Collagen
- Drug Combinations
- Fibrin
- Gentamicins
- Hemostatics
- Inflammation
- Male
- Materials Testing
- Osteogenesis
- Palmitates
- Polyesters
- Rats
- Rats, Inbred Strains
- Waxes