Abstract
Local hemostatics for osseous tissue should preferably be absorbable and biocompatible and should not inhibit osteogenesis. The tissue response and effect on demineralized bone-induced heterotopic osteogenesis in the abdominal muscle of 120 male Wistar rats by different local hemostatics were evaluated by light microscopy and 85Sr uptake analyses. Non-absorbable bone wax of 88% beeswax and absorbable bovine fibrin-collagen paste both significantly inhibited osteoinduction, whereas a bioerodible polyorthoester drug delivery system with or without 4% gentamicin did not. Bone wax was not absorbed and induced a chronic foreign body reaction. Fibrin-collagen paste induced less inflammation with numerous monocytes and macrophages with engulfed material. Bioerodible polyorthoester caused a very moderate tissue reaction and was mostly resorbed at week 4.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Journal of Biomedical Materials Research |
| Vol/bind | 26 |
| Udgave nummer | 6 |
| Sider (fra-til) | 791-800 |
| Antal sider | 10 |
| ISSN | 0021-9304 |
| DOI | |
| Status | Udgivet - 1 jun. 1992 |