Effect of copper nanoparticles administered in ovo on the activity of proliferating cells and on the resistance of femoral bones in broiler chickens

Natalia Mroczek-Sosnowska; Monika Lukasiewicz; Dobrochna Adamek; Maciej Kamaszewski; Jan Niemiec; Agnieszka  Wnuk-Gnich; Abdullah Talal Abdullah Skot; André Chwalibog; Ewa Sawosz

doi:10.1080/1745039X.2017.1331619

Effect of copper nanoparticles administered in ovo on the activity of proliferating cells and on the resistance of femoral bones in broiler chickens

Natalia Mroczek-Sosnowska, Monika Lukasiewicz, Dobrochna Adamek, Maciej Kamaszewski, Jan Niemiec, Agnieszka Wnuk-Gnich, Abdullah Talal Abdullah Skot, André Chwalibog, Ewa Sawosz

15 Citations (Scopus)

Abstract

The objective of this study was to evaluate bone resistance after in ovo administration of copper nanoparticles (NanoCu) and to determine the number of cells positive for proliferating cell nuclear antigen (PCNA) in the femoral bones of broiler chickens (n = 12 per group). The study demonstrated that femoral bones from the NanoCu group were characterised by a higher weight and volume and by significantly greater resistance to fractures compared to the Control group. NanoCu promoted the proliferation of PCNA-positive cells in the long bones of chickens. A significantly higher number of PCNA-positive cells in the bones of birds in the NanoCu group compared with the Control group (137 and 122, respectively) indicate a stimulatory effect during embryogenesis. Considering the improvement in bone resistance to fractures and the effect of NanoCu on the number of PCNA-positive cells in femoral bones, NanoCu may be an alternative agent to minimise the ever-present problem of weak bones in broiler chickens.

Original language	English
Journal	Archives of Animal Nutrition
Volume	71
Issue number	4
Pages (from-to)	327-332
Number of pages	6
ISSN	1745-039X
DOIs	https://doi.org/10.1080/1745039X.2017.1331619
Publication status	Published - 4 Jul 2017

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Mroczek-Sosnowska, N., Lukasiewicz, M., Adamek, D., Kamaszewski, M., Niemiec, J., Wnuk-Gnich, A., Skot, A. T. A., Chwalibog, A., & Sawosz, E. (2017). Effect of copper nanoparticles administered in ovo on the activity of proliferating cells and on the resistance of femoral bones in broiler chickens. Archives of Animal Nutrition, 71(4), 327-332. https://doi.org/10.1080/1745039X.2017.1331619

Effect of copper nanoparticles administered in ovo on the activity of proliferating cells and on the resistance of femoral bones in broiler chickens. / Mroczek-Sosnowska, Natalia; Lukasiewicz, Monika; Adamek, Dobrochna et al.

In: Archives of Animal Nutrition, Vol. 71, No. 4, 04.07.2017, p. 327-332.

Research output: Contribution to journal › Journal article › Research › peer-review

Mroczek-Sosnowska, N, Lukasiewicz, M, Adamek, D, Kamaszewski, M, Niemiec, J, Wnuk-Gnich, A, Skot, ATA , Chwalibog, A & Sawosz, E 2017, 'Effect of copper nanoparticles administered in ovo on the activity of proliferating cells and on the resistance of femoral bones in broiler chickens', Archives of Animal Nutrition, vol. 71, no. 4, pp. 327-332. https://doi.org/10.1080/1745039X.2017.1331619

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abstract = "The objective of this study was to evaluate bone resistance after in ovo administration of copper nanoparticles (NanoCu) and to determine the number of cells positive for proliferating cell nuclear antigen (PCNA) in the femoral bones of broiler chickens (n = 12 per group). The study demonstrated that femoral bones from the NanoCu group were characterised by a higher weight and volume and by significantly greater resistance to fractures compared to the Control group. NanoCu promoted the proliferation of PCNA-positive cells in the long bones of chickens. A significantly higher number of PCNA-positive cells in the bones of birds in the NanoCu group compared with the Control group (137 and 122, respectively) indicate a stimulatory effect during embryogenesis. Considering the improvement in bone resistance to fractures and the effect of NanoCu on the number of PCNA-positive cells in femoral bones, NanoCu may be an alternative agent to minimise the ever-present problem of weak bones in broiler chickens.",

author = "Natalia Mroczek-Sosnowska and Monika Lukasiewicz and Dobrochna Adamek and Maciej Kamaszewski and Jan Niemiec and Agnieszka Wnuk-Gnich and Skot, {Abdullah Talal Abdullah} and Andr{\'e} Chwalibog and Ewa Sawosz",

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AU - Mroczek-Sosnowska, Natalia

AU - Lukasiewicz, Monika

AU - Adamek, Dobrochna

AU - Kamaszewski, Maciej

AU - Niemiec, Jan

AU - Wnuk-Gnich, Agnieszka

AU - Skot, Abdullah Talal Abdullah

AU - Chwalibog, André

AU - Sawosz, Ewa

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N2 - The objective of this study was to evaluate bone resistance after in ovo administration of copper nanoparticles (NanoCu) and to determine the number of cells positive for proliferating cell nuclear antigen (PCNA) in the femoral bones of broiler chickens (n = 12 per group). The study demonstrated that femoral bones from the NanoCu group were characterised by a higher weight and volume and by significantly greater resistance to fractures compared to the Control group. NanoCu promoted the proliferation of PCNA-positive cells in the long bones of chickens. A significantly higher number of PCNA-positive cells in the bones of birds in the NanoCu group compared with the Control group (137 and 122, respectively) indicate a stimulatory effect during embryogenesis. Considering the improvement in bone resistance to fractures and the effect of NanoCu on the number of PCNA-positive cells in femoral bones, NanoCu may be an alternative agent to minimise the ever-present problem of weak bones in broiler chickens.

AB - The objective of this study was to evaluate bone resistance after in ovo administration of copper nanoparticles (NanoCu) and to determine the number of cells positive for proliferating cell nuclear antigen (PCNA) in the femoral bones of broiler chickens (n = 12 per group). The study demonstrated that femoral bones from the NanoCu group were characterised by a higher weight and volume and by significantly greater resistance to fractures compared to the Control group. NanoCu promoted the proliferation of PCNA-positive cells in the long bones of chickens. A significantly higher number of PCNA-positive cells in the bones of birds in the NanoCu group compared with the Control group (137 and 122, respectively) indicate a stimulatory effect during embryogenesis. Considering the improvement in bone resistance to fractures and the effect of NanoCu on the number of PCNA-positive cells in femoral bones, NanoCu may be an alternative agent to minimise the ever-present problem of weak bones in broiler chickens.

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Effect of copper nanoparticles administered in ovo on the activity of proliferating cells and on the resistance of femoral bones in broiler chickens

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