Effect of breed on plasma endothelin-1 concentration, plasma renin activity, and serum cortisol concentration in healthy dogs

K. Höglund; A.-S. Lequarré; I. Ljungvall; K. Mc Entee; A.-C. Merveille; M. Wiberg; V. Gouni; Jakob Willesen; S. Hanås; G. Wess; L. Mejer Sørensen; L. Tiret; M. Kierczak; S. K. G. Forsberg; E. Seppälä; K. Lindblad-Toh; H. Lohi; V. Chetboul; Merete Fredholm; J. Häggström

doi:10.1111/jvim.13829

Effect of breed on plasma endothelin-1 concentration, plasma renin activity, and serum cortisol concentration in healthy dogs

K. Höglund, A.-S. Lequarré, I. Ljungvall, K. Mc Entee, A.-C. Merveille, M. Wiberg, V. Gouni, Jakob Willesen, S. Hanås, G. Wess, L. Mejer Sørensen, L. Tiret, M. Kierczak, S. K. G. Forsberg, E. Seppälä, K. Lindblad-Toh, H. Lohi, V. Chetboul, Merete Fredholm, J. Häggström

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Abstract

Background: There are breed differences in several blood variables in healthy dogs. Objective: Investigate breed variation in plasma endothelin-1 (ET-1) concentration, plasma renin activity, and serum cortisol concentration. Animals: Five-hundred and thirty-one healthy dogs of 9 breeds examined at 5 centers (2-4 breeds/center). Methods: Prospective observational study. Circulating concentrations of ET-1 and cortisol, and renin activity, were measured using commercially available assays. Absence of organ-related or systemic disease was ensured by thorough clinical investigations, including blood pressure measurement, echocardiography, ECG, blood and urine analysis. Results: Median ET-1 concentration was 1.29 (interquartile range [IQR], 0.97-1.82) pg/mL, median cortisol concentration 46.0 (IQR, 29.0-80.8) nmol/L, and median renin activity 0.73 (IQR, 0.48-1.10) ng/mL/h in all dogs. Overall, breed differences were found in ET-1 and cortisol concentrations, and renin activity (P < .0001 for all). Pair-wise comparisons between breeds differed in 67% of comparisons for ET-1, 22% for cortisol, and 19% for renin activity, respectively. Within centers, breed differences were found at 5/5 centers for ET-1, 4/5 centers for cortisol, and 2/5 centers for renin activity. Newfoundlands had highest median ET-1 concentration, 3 times higher than Cavalier King Charles Spaniels, Doberman Pinschers, and Dachshunds. Median renin activity was highest in Dachshunds, twice the median value in Newfoundlands and Boxers. Median cortisol concentration was highest in Finnish Lapphunds, almost 3 times higher than in Boxers. Conclusions and Clinical Importance: Breed variation might be important to take into consideration when interpreting test results in clinical studies.

Original language	English
Journal	Journal of Veterinary Internal Medicine
Volume	30
Issue number	2
Pages (from-to)	566-573
Number of pages	8
ISSN	0891-6640
DOIs	https://doi.org/10.1111/jvim.13829
Publication status	Published - 1 Mar 2016

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Effect of breed on plasma endothelin-1 concentration, plasma renin activity, and serum cortisol concentration in healthy dogsFinal published version, 392 KB

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Höglund, K., Lequarré, A.-S., Ljungvall, I., Mc Entee, K., Merveille, A.-C., Wiberg, M., Gouni, V., Willesen, J., Hanås, S., Wess, G., Mejer Sørensen, L., Tiret, L., Kierczak, M., Forsberg, S. K. G., Seppälä, E., Lindblad-Toh, K., Lohi, H., Chetboul, V., Fredholm, M., & Häggström, J. (2016). Effect of breed on plasma endothelin-1 concentration, plasma renin activity, and serum cortisol concentration in healthy dogs. Journal of Veterinary Internal Medicine, 30(2), 566-573. https://doi.org/10.1111/jvim.13829

Höglund, K, Lequarré, A-S, Ljungvall, I, Mc Entee, K, Merveille, A-C, Wiberg, M, Gouni, V, Willesen, J, Hanås, S, Wess, G, Mejer Sørensen, L, Tiret, L, Kierczak, M, Forsberg, SKG, Seppälä, E, Lindblad-Toh, K, Lohi, H, Chetboul, V, Fredholm, M & Häggström, J 2016, 'Effect of breed on plasma endothelin-1 concentration, plasma renin activity, and serum cortisol concentration in healthy dogs', Journal of Veterinary Internal Medicine, vol. 30, no. 2, pp. 566-573. https://doi.org/10.1111/jvim.13829

@article{8917e00cd537496fac5c7d641c24221a,

title = "Effect of breed on plasma endothelin-1 concentration, plasma renin activity, and serum cortisol concentration in healthy dogs",

abstract = "Background: There are breed differences in several blood variables in healthy dogs. Objective: Investigate breed variation in plasma endothelin-1 (ET-1) concentration, plasma renin activity, and serum cortisol concentration. Animals: Five-hundred and thirty-one healthy dogs of 9 breeds examined at 5 centers (2-4 breeds/center). Methods: Prospective observational study. Circulating concentrations of ET-1 and cortisol, and renin activity, were measured using commercially available assays. Absence of organ-related or systemic disease was ensured by thorough clinical investigations, including blood pressure measurement, echocardiography, ECG, blood and urine analysis. Results: Median ET-1 concentration was 1.29 (interquartile range [IQR], 0.97-1.82) pg/mL, median cortisol concentration 46.0 (IQR, 29.0-80.8) nmol/L, and median renin activity 0.73 (IQR, 0.48-1.10) ng/mL/h in all dogs. Overall, breed differences were found in ET-1 and cortisol concentrations, and renin activity (P < .0001 for all). Pair-wise comparisons between breeds differed in 67% of comparisons for ET-1, 22% for cortisol, and 19% for renin activity, respectively. Within centers, breed differences were found at 5/5 centers for ET-1, 4/5 centers for cortisol, and 2/5 centers for renin activity. Newfoundlands had highest median ET-1 concentration, 3 times higher than Cavalier King Charles Spaniels, Doberman Pinschers, and Dachshunds. Median renin activity was highest in Dachshunds, twice the median value in Newfoundlands and Boxers. Median cortisol concentration was highest in Finnish Lapphunds, almost 3 times higher than in Boxers. Conclusions and Clinical Importance: Breed variation might be important to take into consideration when interpreting test results in clinical studies.",

author = "K. H{\"o}glund and A.-S. Lequarr{\'e} and I. Ljungvall and {Mc Entee}, K. and A.-C. Merveille and M. Wiberg and V. Gouni and Jakob Willesen and S. Han{\aa}s and G. Wess and {Mejer S{\o}rensen}, L. and L. Tiret and M. Kierczak and Forsberg, {S. K. G.} and E. Sepp{\"a}l{\"a} and K. Lindblad-Toh and H. Lohi and V. Chetboul and Merete Fredholm and J. H{\"a}ggstr{\"o}m",

note = "Copyright {\textcopyright} 2016 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.",

year = "2016",

month = mar,

day = "1",

doi = "10.1111/jvim.13829",

language = "English",

volume = "30",

pages = "566--573",

journal = "Journal of Veterinary Internal Medicine",

issn = "0891-6640",

publisher = "Wiley-Blackwell",

number = "2",

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TY - JOUR

T1 - Effect of breed on plasma endothelin-1 concentration, plasma renin activity, and serum cortisol concentration in healthy dogs

AU - Höglund, K.

AU - Lequarré, A.-S.

AU - Ljungvall, I.

AU - Mc Entee, K.

AU - Merveille, A.-C.

AU - Wiberg, M.

AU - Gouni, V.

AU - Willesen, Jakob

AU - Hanås, S.

AU - Wess, G.

AU - Mejer Sørensen, L.

AU - Tiret, L.

AU - Kierczak, M.

AU - Forsberg, S. K. G.

AU - Seppälä, E.

AU - Lindblad-Toh, K.

AU - Lohi, H.

AU - Chetboul, V.

AU - Fredholm, Merete

AU - Häggström, J.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background: There are breed differences in several blood variables in healthy dogs. Objective: Investigate breed variation in plasma endothelin-1 (ET-1) concentration, plasma renin activity, and serum cortisol concentration. Animals: Five-hundred and thirty-one healthy dogs of 9 breeds examined at 5 centers (2-4 breeds/center). Methods: Prospective observational study. Circulating concentrations of ET-1 and cortisol, and renin activity, were measured using commercially available assays. Absence of organ-related or systemic disease was ensured by thorough clinical investigations, including blood pressure measurement, echocardiography, ECG, blood and urine analysis. Results: Median ET-1 concentration was 1.29 (interquartile range [IQR], 0.97-1.82) pg/mL, median cortisol concentration 46.0 (IQR, 29.0-80.8) nmol/L, and median renin activity 0.73 (IQR, 0.48-1.10) ng/mL/h in all dogs. Overall, breed differences were found in ET-1 and cortisol concentrations, and renin activity (P < .0001 for all). Pair-wise comparisons between breeds differed in 67% of comparisons for ET-1, 22% for cortisol, and 19% for renin activity, respectively. Within centers, breed differences were found at 5/5 centers for ET-1, 4/5 centers for cortisol, and 2/5 centers for renin activity. Newfoundlands had highest median ET-1 concentration, 3 times higher than Cavalier King Charles Spaniels, Doberman Pinschers, and Dachshunds. Median renin activity was highest in Dachshunds, twice the median value in Newfoundlands and Boxers. Median cortisol concentration was highest in Finnish Lapphunds, almost 3 times higher than in Boxers. Conclusions and Clinical Importance: Breed variation might be important to take into consideration when interpreting test results in clinical studies.

AB - Background: There are breed differences in several blood variables in healthy dogs. Objective: Investigate breed variation in plasma endothelin-1 (ET-1) concentration, plasma renin activity, and serum cortisol concentration. Animals: Five-hundred and thirty-one healthy dogs of 9 breeds examined at 5 centers (2-4 breeds/center). Methods: Prospective observational study. Circulating concentrations of ET-1 and cortisol, and renin activity, were measured using commercially available assays. Absence of organ-related or systemic disease was ensured by thorough clinical investigations, including blood pressure measurement, echocardiography, ECG, blood and urine analysis. Results: Median ET-1 concentration was 1.29 (interquartile range [IQR], 0.97-1.82) pg/mL, median cortisol concentration 46.0 (IQR, 29.0-80.8) nmol/L, and median renin activity 0.73 (IQR, 0.48-1.10) ng/mL/h in all dogs. Overall, breed differences were found in ET-1 and cortisol concentrations, and renin activity (P < .0001 for all). Pair-wise comparisons between breeds differed in 67% of comparisons for ET-1, 22% for cortisol, and 19% for renin activity, respectively. Within centers, breed differences were found at 5/5 centers for ET-1, 4/5 centers for cortisol, and 2/5 centers for renin activity. Newfoundlands had highest median ET-1 concentration, 3 times higher than Cavalier King Charles Spaniels, Doberman Pinschers, and Dachshunds. Median renin activity was highest in Dachshunds, twice the median value in Newfoundlands and Boxers. Median cortisol concentration was highest in Finnish Lapphunds, almost 3 times higher than in Boxers. Conclusions and Clinical Importance: Breed variation might be important to take into consideration when interpreting test results in clinical studies.

U2 - 10.1111/jvim.13829

DO - 10.1111/jvim.13829

M3 - Journal article

C2 - 26812988

SN - 0891-6640

VL - 30

SP - 566

EP - 573

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

IS - 2

ER -

Effect of breed on plasma endothelin-1 concentration, plasma renin activity, and serum cortisol concentration in healthy dogs

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