Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers

Dimitrios Andreou; Peter Saetre; Anna K Kähler; Thomas Werge; Ole A Andreassen; Ingrid Agartz; Göran C Sedvall; Håkan Hall; Lars Terenius; Erik G Jönsson

doi:10.1016/j.euroneuro.2010.12.008

Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers

Dimitrios Andreou, Peter Saetre, Anna K Kähler, Thomas Werge, Ole A Andreassen, Ingrid Agartz, Göran C Sedvall, Håkan Hall, Lars Terenius, Erik G Jönsson

2 Citations (Scopus)

Abstract

The dystrobrevin binding protein-1 (DTNBP1) gene encodes dysbindin-1, a protein involved in neurodevelopmental and neurochemical processes related mainly to the monoamine dopamine. We investigated possible associations between eleven DTNBP1 polymorphisms and cerebrospinal fluid (CSF) concentrations of the major dopamine metabolite homovanillic acid (HVA), the major serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), and the major noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy human subjects (n=132). Two polymorphisms, rs2619538 and rs760666, were nominally associated with CSF HVA and 5-HIAA concentrations, whereas a third polymorphism, rs909706, showed association only with HVA. After correction for multiple testing only the associations between rs2619538 and HVA and 5-HIAA concentrations remained significant. No significant association was found between any of the investigated DTNBP1 polymorphisms and CSF MHPG concentrations. The results suggest that genetic variation in DTNBP1 gene affects the regulation of dopamine and serotonin turnover in the central nervous system of healthy volunteers.

Original language	English
Journal	European Neuropsychopharmacology
Volume	21
Issue number	9
Pages (from-to)	700-4
Number of pages	5
ISSN	0924-977X
DOIs	https://doi.org/10.1016/j.euroneuro.2010.12.008
Publication status	Published - Sept 2011

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Andreou, D., Saetre, P., Kähler, A. K., Werge, T., Andreassen, O. A., Agartz, I., Sedvall, G. C., Hall, H., Terenius, L., & Jönsson, E. G. (2011). Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers. European Neuropsychopharmacology, 21(9), 700-4. https://doi.org/10.1016/j.euroneuro.2010.12.008

Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers. / Andreou, Dimitrios; Saetre, Peter; Kähler, Anna K et al.

In: European Neuropsychopharmacology, Vol. 21, No. 9, 09.2011, p. 700-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Andreou, D, Saetre, P, Kähler, AK, Werge, T, Andreassen, OA, Agartz, I, Sedvall, GC, Hall, H, Terenius, L & Jönsson, EG 2011, 'Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers', European Neuropsychopharmacology, vol. 21, no. 9, pp. 700-4. https://doi.org/10.1016/j.euroneuro.2010.12.008

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title = "Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers",

abstract = "The dystrobrevin binding protein-1 (DTNBP1) gene encodes dysbindin-1, a protein involved in neurodevelopmental and neurochemical processes related mainly to the monoamine dopamine. We investigated possible associations between eleven DTNBP1 polymorphisms and cerebrospinal fluid (CSF) concentrations of the major dopamine metabolite homovanillic acid (HVA), the major serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), and the major noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy human subjects (n=132). Two polymorphisms, rs2619538 and rs760666, were nominally associated with CSF HVA and 5-HIAA concentrations, whereas a third polymorphism, rs909706, showed association only with HVA. After correction for multiple testing only the associations between rs2619538 and HVA and 5-HIAA concentrations remained significant. No significant association was found between any of the investigated DTNBP1 polymorphisms and CSF MHPG concentrations. The results suggest that genetic variation in DTNBP1 gene affects the regulation of dopamine and serotonin turnover in the central nervous system of healthy volunteers.",

author = "Dimitrios Andreou and Peter Saetre and K{\"a}hler, {Anna K} and Thomas Werge and Andreassen, {Ole A} and Ingrid Agartz and Sedvall, {G{\"o}ran C} and H{\aa}kan Hall and Lars Terenius and J{\"o}nsson, {Erik G}",

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T1 - Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers

AU - Andreou, Dimitrios

AU - Saetre, Peter

AU - Kähler, Anna K

AU - Werge, Thomas

AU - Andreassen, Ole A

AU - Agartz, Ingrid

AU - Sedvall, Göran C

AU - Hall, Håkan

AU - Terenius, Lars

AU - Jönsson, Erik G

PY - 2011/9

Y1 - 2011/9

N2 - The dystrobrevin binding protein-1 (DTNBP1) gene encodes dysbindin-1, a protein involved in neurodevelopmental and neurochemical processes related mainly to the monoamine dopamine. We investigated possible associations between eleven DTNBP1 polymorphisms and cerebrospinal fluid (CSF) concentrations of the major dopamine metabolite homovanillic acid (HVA), the major serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), and the major noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy human subjects (n=132). Two polymorphisms, rs2619538 and rs760666, were nominally associated with CSF HVA and 5-HIAA concentrations, whereas a third polymorphism, rs909706, showed association only with HVA. After correction for multiple testing only the associations between rs2619538 and HVA and 5-HIAA concentrations remained significant. No significant association was found between any of the investigated DTNBP1 polymorphisms and CSF MHPG concentrations. The results suggest that genetic variation in DTNBP1 gene affects the regulation of dopamine and serotonin turnover in the central nervous system of healthy volunteers.

AB - The dystrobrevin binding protein-1 (DTNBP1) gene encodes dysbindin-1, a protein involved in neurodevelopmental and neurochemical processes related mainly to the monoamine dopamine. We investigated possible associations between eleven DTNBP1 polymorphisms and cerebrospinal fluid (CSF) concentrations of the major dopamine metabolite homovanillic acid (HVA), the major serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), and the major noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy human subjects (n=132). Two polymorphisms, rs2619538 and rs760666, were nominally associated with CSF HVA and 5-HIAA concentrations, whereas a third polymorphism, rs909706, showed association only with HVA. After correction for multiple testing only the associations between rs2619538 and HVA and 5-HIAA concentrations remained significant. No significant association was found between any of the investigated DTNBP1 polymorphisms and CSF MHPG concentrations. The results suggest that genetic variation in DTNBP1 gene affects the regulation of dopamine and serotonin turnover in the central nervous system of healthy volunteers.

U2 - 10.1016/j.euroneuro.2010.12.008

DO - 10.1016/j.euroneuro.2010.12.008

M3 - Journal article

C2 - 21295953

SN - 0924-977X

VL - 21

SP - 700

EP - 704

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

IS - 9

ER -

Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers

Abstract

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