Dynamic epigenetic responses to muscle contraction

Morten Rasmussen; Juleen R Zierath; Romain Barrès

doi:10.1016/j.drudis.2014.03.003

Dynamic epigenetic responses to muscle contraction

Morten Rasmussen, Juleen R Zierath, Romain Barrès

21 Citations (Scopus)

Abstract

Skeletal muscle is a malleable organ that responds to a single acute exercise bout by inducing the expression of genes involved in structural, metabolic and functional adaptations. Several epigenetic mechanisms including histone H4 deacetylation and loss of promoter methylation have been implicated in modifying exercise-responsive gene expression. These transient changes suggest that epigenetic mechanisms are not restricted to early stages of human development but are broad dynamic controllers of genomic plasticity in response to environmental factors.

Original language	English
Journal	Drug Discovery Today
Volume	19
Issue number	7
Pages (from-to)	1010-4
Number of pages	5
ISSN	1359-6446
DOIs	https://doi.org/10.1016/j.drudis.2014.03.003
Publication status	Published - 19 Jul 2014

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title = "Dynamic epigenetic responses to muscle contraction",

abstract = "Skeletal muscle is a malleable organ that responds to a single acute exercise bout by inducing the expression of genes involved in structural, metabolic and functional adaptations. Several epigenetic mechanisms including histone H4 deacetylation and loss of promoter methylation have been implicated in modifying exercise-responsive gene expression. These transient changes suggest that epigenetic mechanisms are not restricted to early stages of human development but are broad dynamic controllers of genomic plasticity in response to environmental factors.",

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AU - Rasmussen, Morten

AU - Zierath, Juleen R

AU - Barrès, Romain

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AB - Skeletal muscle is a malleable organ that responds to a single acute exercise bout by inducing the expression of genes involved in structural, metabolic and functional adaptations. Several epigenetic mechanisms including histone H4 deacetylation and loss of promoter methylation have been implicated in modifying exercise-responsive gene expression. These transient changes suggest that epigenetic mechanisms are not restricted to early stages of human development but are broad dynamic controllers of genomic plasticity in response to environmental factors.

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DO - 10.1016/j.drudis.2014.03.003

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JO - Drug Discovery Today: BIOSILICO

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Dynamic epigenetic responses to muscle contraction

Abstract

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