Dynamic epigenetic responses to muscle contraction

TY - JOUR

T1 - Dynamic epigenetic responses to muscle contraction

AU - Rasmussen, Morten

AU - Zierath, Juleen R

AU - Barrès, Romain

PY - 2014/7/19

Y1 - 2014/7/19

N2 - Skeletal muscle is a malleable organ that responds to a single acute exercise bout by inducing the expression of genes involved in structural, metabolic and functional adaptations. Several epigenetic mechanisms including histone H4 deacetylation and loss of promoter methylation have been implicated in modifying exercise-responsive gene expression. These transient changes suggest that epigenetic mechanisms are not restricted to early stages of human development but are broad dynamic controllers of genomic plasticity in response to environmental factors.

AB - Skeletal muscle is a malleable organ that responds to a single acute exercise bout by inducing the expression of genes involved in structural, metabolic and functional adaptations. Several epigenetic mechanisms including histone H4 deacetylation and loss of promoter methylation have been implicated in modifying exercise-responsive gene expression. These transient changes suggest that epigenetic mechanisms are not restricted to early stages of human development but are broad dynamic controllers of genomic plasticity in response to environmental factors.

U2 - 10.1016/j.drudis.2014.03.003

DO - 10.1016/j.drudis.2014.03.003

M3 - Review

C2 - 24631681

SN - 1359-6446

VL - 19

SP - 1010

EP - 1014

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 7

ER -