Dual association of a TRKA polymorphism with schizophrenia

Jessica E Van Schijndel; Martine Van Zweeden; Karen M J Van Loo; Srdjan Djurovic; Ole A Andreassen; Thomas Hansen; Thomas Werge; Mette Nyegaard; Karina Meden Sørensen; Merete Nordentoft; Preben Bo Mortensen; Ole Mors; Anders Børglum; Jurgen Del-Favero; Karl-Fredrik Norrback; Rolf Adolfsson; Marc De Hert; Stephan Claes; Sven Cichon; Marcella Rietschel; Markus M Nöthen; Pekka Kallunki; Jan T Pedersen; Gerard J M Martens

doi:10.1097/ypg.0b013e3283437194

Dual association of a TRKA polymorphism with schizophrenia

Jessica E Van Schijndel, Martine Van Zweeden, Karen M J Van Loo, Srdjan Djurovic, Ole A Andreassen, Thomas Hansen, Thomas Werge, Mette Nyegaard, Karina Meden Sørensen, Merete Nordentoft, Preben Bo Mortensen, Ole Mors, Anders Børglum, Jurgen Del-Favero, Karl-Fredrik Norrback, Rolf Adolfsson, Marc De Hert, Stephan Claes, Sven Cichon, Marcella RietschelMarkus M Nöthen, Pekka Kallunki, Jan T Pedersen, Gerard J M Martens

8 Citations (Scopus)

Abstract

OBJECTIVE: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor. METHODS: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups. RESULT: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor. CONCLUSION: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors.

Original language	English
Journal	Psychiatric Genetics
Volume	21
Issue number	3
Pages (from-to)	125-31
Number of pages	7
ISSN	0955-8829
DOIs	https://doi.org/10.1097/ypg.0b013e3283437194
Publication status	Published - Jun 2011

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Van Schijndel, J. E., Van Zweeden, M., Van Loo, K. M. J., Djurovic, S., Andreassen, O. A., Hansen, T., Werge, T., Nyegaard, M., Sørensen, K. M., Nordentoft, M., Mortensen, P. B., Mors, O., Børglum, A., Del-Favero, J., Norrback, K-F., Adolfsson, R., Hert, M. D., Claes, S., Cichon, S., ... Martens, G. J. M. (2011). Dual association of a TRKA polymorphism with schizophrenia. Psychiatric Genetics, 21(3), 125-31. https://doi.org/10.1097/ypg.0b013e3283437194

Van Schijndel, JE, Van Zweeden, M, Van Loo, KMJ, Djurovic, S, Andreassen, OA, Hansen, T , Werge, T, Nyegaard, M, Sørensen, KM, Nordentoft, M, Mortensen, PB, Mors, O, Børglum, A, Del-Favero, J, Norrback, K-F, Adolfsson, R, Hert, MD, Claes, S, Cichon, S, Rietschel, M, Nöthen, MM, Kallunki, P, Pedersen, JT & Martens, GJM 2011, 'Dual association of a TRKA polymorphism with schizophrenia', Psychiatric Genetics, vol. 21, no. 3, pp. 125-31. https://doi.org/10.1097/ypg.0b013e3283437194

@article{e89269f094334cd1981376318046405e,

title = "Dual association of a TRKA polymorphism with schizophrenia",

abstract = "OBJECTIVE: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor. METHODS: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups. RESULT: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor. CONCLUSION: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors.",

author = "{Van Schijndel}, {Jessica E} and {Van Zweeden}, Martine and {Van Loo}, {Karen M J} and Srdjan Djurovic and Andreassen, {Ole A} and Thomas Hansen and Thomas Werge and Mette Nyegaard and S{\o}rensen, {Karina Meden} and Merete Nordentoft and Mortensen, {Preben Bo} and Ole Mors and Anders B{\o}rglum and Jurgen Del-Favero and Karl-Fredrik Norrback and Rolf Adolfsson and Hert, {Marc De} and Stephan Claes and Sven Cichon and Marcella Rietschel and N{\"o}then, {Markus M} and Pekka Kallunki and Pedersen, {Jan T} and Martens, {Gerard J M}",

year = "2011",

month = jun,

doi = "10.1097/ypg.0b013e3283437194",

language = "English",

volume = "21",

pages = "125--31",

journal = "Psychiatric Genetics",

issn = "0955-8829",

publisher = "Lippincott Williams & Wilkins",

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TY - JOUR

T1 - Dual association of a TRKA polymorphism with schizophrenia

AU - Van Schijndel, Jessica E

AU - Van Zweeden, Martine

AU - Van Loo, Karen M J

AU - Djurovic, Srdjan

AU - Andreassen, Ole A

AU - Hansen, Thomas

AU - Werge, Thomas

AU - Nyegaard, Mette

AU - Sørensen, Karina Meden

AU - Nordentoft, Merete

AU - Mortensen, Preben Bo

AU - Mors, Ole

AU - Børglum, Anders

AU - Del-Favero, Jurgen

AU - Norrback, Karl-Fredrik

AU - Adolfsson, Rolf

AU - Hert, Marc De

AU - Claes, Stephan

AU - Cichon, Sven

AU - Rietschel, Marcella

AU - Nöthen, Markus M

AU - Kallunki, Pekka

AU - Pedersen, Jan T

AU - Martens, Gerard J M

PY - 2011/6

Y1 - 2011/6

N2 - OBJECTIVE: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor. METHODS: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups. RESULT: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor. CONCLUSION: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors.

AB - OBJECTIVE: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor. METHODS: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups. RESULT: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor. CONCLUSION: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors.

U2 - 10.1097/ypg.0b013e3283437194

DO - 10.1097/ypg.0b013e3283437194

M3 - Journal article

C2 - 21317683

SN - 0955-8829

VL - 21

SP - 125

EP - 131

JO - Psychiatric Genetics

JF - Psychiatric Genetics

IS - 3

ER -

Dual association of a TRKA polymorphism with schizophrenia

Abstract

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