Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles

Ziaur Rehman Tanoli; Zaid Alam; Markus Vähä-Koskela; Balaguru Ravikumar; Alina Malyutina; Alok Jaiswal; Jing Tang; Krister Wennerberg; Tero Aittokallio

doi:10.1093/database/bay083

Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles

Ziaur Rehman Tanoli^*, Zaid Alam, Markus Vähä-Koskela, Balaguru Ravikumar, Alina Malyutina, Alok Jaiswal, Jing Tang, Krister Wennerberg, Tero Aittokallio

^*Corresponding author for this work

16 Citations (Scopus)

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Abstract

Drug Target Commons (DTC) is a web platform (database with user interface) for community-driven bioactivity data integration and standardization for comprehensive mapping, reuse and analysis of compound-target interaction profiles. End users can search, upload, edit, annotate and export expert-curated bioactivity data for further analysis, using an application programmable interface, database dump or tab-delimited text download options. To guide chemical biology and drug-repurposing applications, DTC version 2.0 includes updated clinical development information for the compounds and target gene-disease associations, as well as cancer-type indications for mutant protein targets, which are critical for precision oncology developments.

Original language	English
Article number	bay083
Journal	Database: The Journal of Biological Databases and Curation
Volume	2018
Issue number	2018
Pages (from-to)	1-13
Number of pages	13
ISSN	1758-0463
DOIs	https://doi.org/10.1093/database/bay083
Publication status	Published - 2018

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Drug Target Commons 2.0: a community platform for systematic analysis of drug – target interaction profilesFinal published version, 15.3 MBLicence: CC BY

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Tanoli, Z. R., Alam, Z., Vähä-Koskela, M., Ravikumar, B., Malyutina, A., Jaiswal, A., Tang, J., Wennerberg, K., & Aittokallio, T. (2018). Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles. Database: The Journal of Biological Databases and Curation, 2018(2018), 1-13. Article bay083. https://doi.org/10.1093/database/bay083

Tanoli, ZR, Alam, Z, Vähä-Koskela, M, Ravikumar, B, Malyutina, A, Jaiswal, A, Tang, J, Wennerberg, K & Aittokallio, T 2018, 'Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles', Database: The Journal of Biological Databases and Curation, vol. 2018, no. 2018, bay083, pp. 1-13. https://doi.org/10.1093/database/bay083

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AU - Ravikumar, Balaguru

AU - Malyutina, Alina

AU - Jaiswal, Alok

AU - Tang, Jing

AU - Wennerberg, Krister

AU - Aittokallio, Tero

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Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles

Abstract

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