Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles

Ziaur Rehman Tanoli; Zaid Alam; Markus Vähä-Koskela; Balaguru Ravikumar; Alina Malyutina; Alok Jaiswal; Jing Tang; Krister Wennerberg; Tero Aittokallio

doi:10.1093/database/bay083

Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles

Ziaur Rehman Tanoli^*, Zaid Alam, Markus Vähä-Koskela, Balaguru Ravikumar, Alina Malyutina, Alok Jaiswal, Jing Tang, Krister Wennerberg, Tero Aittokallio

^*Corresponding author af dette arbejde

16 Citationer (Scopus)

62 Downloads (Pure)

Abstract

Drug Target Commons (DTC) is a web platform (database with user interface) for community-driven bioactivity data integration and standardization for comprehensive mapping, reuse and analysis of compound-target interaction profiles. End users can search, upload, edit, annotate and export expert-curated bioactivity data for further analysis, using an application programmable interface, database dump or tab-delimited text download options. To guide chemical biology and drug-repurposing applications, DTC version 2.0 includes updated clinical development information for the compounds and target gene-disease associations, as well as cancer-type indications for mutant protein targets, which are critical for precision oncology developments.

Originalsprog	Engelsk
Artikelnummer	bay083
Tidsskrift	Database: The Journal of Biological Databases and Curation
Vol/bind	2018
Udgave nummer	2018
Sider (fra-til)	1-13
Antal sider	13
ISSN	1758-0463
DOI	https://doi.org/10.1093/database/bay083
Status	Udgivet - 2018

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10.1093/database/bay083Licens: CC BY

Drug Target Commons 2.0: a community platform for systematic analysis of drug – target interaction profilesForlagets udgivne version, 15,3 MBLicens: CC BY

Citationsformater

Tanoli, Z. R., Alam, Z., Vähä-Koskela, M., Ravikumar, B., Malyutina, A., Jaiswal, A., Tang, J., Wennerberg, K., & Aittokallio, T. (2018). Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles. Database: The Journal of Biological Databases and Curation, 2018(2018), 1-13. Artikel bay083. https://doi.org/10.1093/database/bay083

Tanoli, ZR, Alam, Z, Vähä-Koskela, M, Ravikumar, B, Malyutina, A, Jaiswal, A, Tang, J, Wennerberg, K & Aittokallio, T 2018, 'Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles', Database: The Journal of Biological Databases and Curation, bind 2018, nr. 2018, bay083, s. 1-13. https://doi.org/10.1093/database/bay083

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AU - Vähä-Koskela, Markus

AU - Ravikumar, Balaguru

AU - Malyutina, Alina

AU - Jaiswal, Alok

AU - Tang, Jing

AU - Wennerberg, Krister

AU - Aittokallio, Tero

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AB - Drug Target Commons (DTC) is a web platform (database with user interface) for community-driven bioactivity data integration and standardization for comprehensive mapping, reuse and analysis of compound-target interaction profiles. End users can search, upload, edit, annotate and export expert-curated bioactivity data for further analysis, using an application programmable interface, database dump or tab-delimited text download options. To guide chemical biology and drug-repurposing applications, DTC version 2.0 includes updated clinical development information for the compounds and target gene-disease associations, as well as cancer-type indications for mutant protein targets, which are critical for precision oncology developments.

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Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles

Abstract

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