Abstract
Glucagon-like peptide-1 (GLP-1) has shown to influence the oxidative stress status in a number of in vitro, in vivo and clinical studies. Well-known effects of GLP-1 including better glycemic control, decreased food intake, increased insulin release and increased insulin sensitivity may indirectly contribute to this phenomenon, but glucose-independent effects on ROS level, production and antioxidant capacity have been suggested to also play a role. The potential 'antioxidant' activity of GLP-1 along with other proposed glucose-independent modes of action related to ameliorating redox imbalance remains a controversial topic but could hold a therapeutic potential against micro- and macrovascular diabetic complications. This review discusses the presently available knowledge from experimental and clinical studies on the effects of GLP-1 on oxidative stress in diabetes and diabetes-related complications.
| Original language | English |
|---|---|
| Journal | Current Diabetes Reviews |
| Volume | 12 |
| Issue number | 4 |
| Pages (from-to) | 331-358 |
| Number of pages | 28 |
| ISSN | 1573-3998 |
| DOIs | |
| Publication status | Published - 1 Dec 2016 |
Keywords
- Animals
- Diabetes Mellitus, Type 2
- Drug Evaluation, Preclinical
- Evidence-Based Practice
- Glucagon-Like Peptide 1
- Humans
- Oxidative Stress
- Peptides
- Reactive Oxygen Species
- Venoms
- Journal Article
- Review
