Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals

TY - JOUR

T1 - Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals

AU - Andersson, Ehm A

AU - Pilgaard, Kasper

AU - Pisinger, Charlotta

AU - Harder, Marie N

AU - Grarup, Niels

AU - Færch, Kristine

AU - Sandholt, Camilla

AU - Poulsen, Pernille

AU - Witte, Daniel R

AU - Jørgensen, Torben

AU - Vaag, Allan

AU - Pedersen, Oluf

AU - Hansen, Torben

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Background: Several obesity risk alleles affecting adult adiposity have been identified by the recent wave of genome wide association studies. We aimed to examine the potential effect of these variants on fetal body composition by investigating the variants in relation to birth weight and ponderal index of the newborn. Methodology/Principal Findings: Midwife records from the Danish State Archives provided information on mother's age, parity, as well as birth weight, birth length and prematurity of the newborn in 4,744 individuals of the population-based Inter99 study. Twenty-four risk alleles showing genome-wide associations with adult BMI and/or waist circumference were genotyped. None of the 24 risk variants tested showed an association with birth weight or ponderal index after correction for multiple testing. Birth weight was divided into three categories low (<10th percentile), normal (10th-90th percentile) and high birth weight (>90th percentile) to allow for non-linear associations. There was no difference in the number of risk alleles between the groups (p = 0.57). No interactions between each risk allele and birth weight in the prediction of adult BMI were observed. An obesity risk score was created by summing up risk alleles. The risk score did not associate with fetal body composition. Moreover there was no interaction between the risk score and birth weight/ponderal index in the prediction of adult BMI.

AB - Background: Several obesity risk alleles affecting adult adiposity have been identified by the recent wave of genome wide association studies. We aimed to examine the potential effect of these variants on fetal body composition by investigating the variants in relation to birth weight and ponderal index of the newborn. Methodology/Principal Findings: Midwife records from the Danish State Archives provided information on mother's age, parity, as well as birth weight, birth length and prematurity of the newborn in 4,744 individuals of the population-based Inter99 study. Twenty-four risk alleles showing genome-wide associations with adult BMI and/or waist circumference were genotyped. None of the 24 risk variants tested showed an association with birth weight or ponderal index after correction for multiple testing. Birth weight was divided into three categories low (<10th percentile), normal (10th-90th percentile) and high birth weight (>90th percentile) to allow for non-linear associations. There was no difference in the number of risk alleles between the groups (p = 0.57). No interactions between each risk allele and birth weight in the prediction of adult BMI were observed. An obesity risk score was created by summing up risk alleles. The risk score did not associate with fetal body composition. Moreover there was no interaction between the risk score and birth weight/ponderal index in the prediction of adult BMI.

U2 - 10.1371/journal.pone.0014190

DO - 10.1371/journal.pone.0014190

M3 - Journal article

C2 - 21152014

SN - 1932-6203

VL - 5

SP - e14190

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 12

ER -