Discovery and uses of pegvisomant: A growth hormone antagonist

Darlene E. Berryman; Amanda J. Palmer; Elahu S. Gosney; Svetha Swaminathan; Dave DeSantis; John J. Kopchick

Discovery and uses of pegvisomant: A growth hormone antagonist

Darlene E. Berryman^*, Amanda J. Palmer, Elahu S. Gosney, Svetha Swaminathan, Dave DeSantis, John J. Kopchick

^*Corresponding author for this work

4 Citations (Scopus)

Abstract

Growth hormone (GH) is a well established participant in several complex physiological processes including growth, differentiation, and metabolism. Recombinant human GH is a drug that has been approved for use for several clinical conditions where the action of GH is diminished or completely lacking. Thus there is considerable interest in developing novel drugs that modify the function of GH. Only in the last several decades have the detailed structural features of GH along with its interaction with its receptor been elucidated. In this review we summarise the basic structural and functional properties of GH, its receptor and their interaction. In addition, we discuss the discovery and development of an effective GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug.

Original language	English
Journal	Endokrynologia Polska
Volume	58
Issue number	4
Pages (from-to)	322-329
Number of pages	8
ISSN	0423-104X
Publication status	Published - 1 Dec 2007

Keywords

Growth hormone
Growth hormone receptor
Growth hormone receptor antagonist

Cite this

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title = "Discovery and uses of pegvisomant: A growth hormone antagonist",

abstract = "Growth hormone (GH) is a well established participant in several complex physiological processes including growth, differentiation, and metabolism. Recombinant human GH is a drug that has been approved for use for several clinical conditions where the action of GH is diminished or completely lacking. Thus there is considerable interest in developing novel drugs that modify the function of GH. Only in the last several decades have the detailed structural features of GH along with its interaction with its receptor been elucidated. In this review we summarise the basic structural and functional properties of GH, its receptor and their interaction. In addition, we discuss the discovery and development of an effective GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug.",

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AU - Berryman, Darlene E.

AU - Palmer, Amanda J.

AU - Gosney, Elahu S.

AU - Swaminathan, Svetha

AU - DeSantis, Dave

AU - Kopchick, John J.

PY - 2007/12/1

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N2 - Growth hormone (GH) is a well established participant in several complex physiological processes including growth, differentiation, and metabolism. Recombinant human GH is a drug that has been approved for use for several clinical conditions where the action of GH is diminished or completely lacking. Thus there is considerable interest in developing novel drugs that modify the function of GH. Only in the last several decades have the detailed structural features of GH along with its interaction with its receptor been elucidated. In this review we summarise the basic structural and functional properties of GH, its receptor and their interaction. In addition, we discuss the discovery and development of an effective GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug.

AB - Growth hormone (GH) is a well established participant in several complex physiological processes including growth, differentiation, and metabolism. Recombinant human GH is a drug that has been approved for use for several clinical conditions where the action of GH is diminished or completely lacking. Thus there is considerable interest in developing novel drugs that modify the function of GH. Only in the last several decades have the detailed structural features of GH along with its interaction with its receptor been elucidated. In this review we summarise the basic structural and functional properties of GH, its receptor and their interaction. In addition, we discuss the discovery and development of an effective GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug.

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KW - Growth hormone receptor

KW - Growth hormone receptor antagonist

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AN - SCOPUS:38449118318

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JF - Endokrynologia Polska

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ER -

Discovery and uses of pegvisomant: A growth hormone antagonist

Abstract

Keywords

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