Discovery and uses of pegvisomant: A growth hormone antagonist

Darlene E. Berryman; Amanda J. Palmer; Elahu S. Gosney; Svetha Swaminathan; Dave DeSantis; John J. Kopchick

Discovery and uses of pegvisomant: A growth hormone antagonist

Darlene E. Berryman^*, Amanda J. Palmer, Elahu S. Gosney, Svetha Swaminathan, Dave DeSantis, John J. Kopchick

^*Corresponding author af dette arbejde

4 Citationer (Scopus)

Abstract

Growth hormone (GH) is a well established participant in several complex physiological processes including growth, differentiation, and metabolism. Recombinant human GH is a drug that has been approved for use for several clinical conditions where the action of GH is diminished or completely lacking. Thus there is considerable interest in developing novel drugs that modify the function of GH. Only in the last several decades have the detailed structural features of GH along with its interaction with its receptor been elucidated. In this review we summarise the basic structural and functional properties of GH, its receptor and their interaction. In addition, we discuss the discovery and development of an effective GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug.

Originalsprog	Engelsk
Tidsskrift	Endokrynologia Polska
Vol/bind	58
Udgave nummer	4
Sider (fra-til)	322-329
Antal sider	8
ISSN	0423-104X
Status	Udgivet - 1 dec. 2007

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Citationsformater

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title = "Discovery and uses of pegvisomant: A growth hormone antagonist",

abstract = "Growth hormone (GH) is a well established participant in several complex physiological processes including growth, differentiation, and metabolism. Recombinant human GH is a drug that has been approved for use for several clinical conditions where the action of GH is diminished or completely lacking. Thus there is considerable interest in developing novel drugs that modify the function of GH. Only in the last several decades have the detailed structural features of GH along with its interaction with its receptor been elucidated. In this review we summarise the basic structural and functional properties of GH, its receptor and their interaction. In addition, we discuss the discovery and development of an effective GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug.",

keywords = "Growth hormone, Growth hormone receptor, Growth hormone receptor antagonist",

author = "Berryman, {Darlene E.} and Palmer, {Amanda J.} and Gosney, {Elahu S.} and Svetha Swaminathan and Dave DeSantis and Kopchick, {John J.}",

year = "2007",

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TY - JOUR

T1 - Discovery and uses of pegvisomant

T2 - A growth hormone antagonist

AU - Berryman, Darlene E.

AU - Palmer, Amanda J.

AU - Gosney, Elahu S.

AU - Swaminathan, Svetha

AU - DeSantis, Dave

AU - Kopchick, John J.

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Growth hormone (GH) is a well established participant in several complex physiological processes including growth, differentiation, and metabolism. Recombinant human GH is a drug that has been approved for use for several clinical conditions where the action of GH is diminished or completely lacking. Thus there is considerable interest in developing novel drugs that modify the function of GH. Only in the last several decades have the detailed structural features of GH along with its interaction with its receptor been elucidated. In this review we summarise the basic structural and functional properties of GH, its receptor and their interaction. In addition, we discuss the discovery and development of an effective GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug.

AB - Growth hormone (GH) is a well established participant in several complex physiological processes including growth, differentiation, and metabolism. Recombinant human GH is a drug that has been approved for use for several clinical conditions where the action of GH is diminished or completely lacking. Thus there is considerable interest in developing novel drugs that modify the function of GH. Only in the last several decades have the detailed structural features of GH along with its interaction with its receptor been elucidated. In this review we summarise the basic structural and functional properties of GH, its receptor and their interaction. In addition, we discuss the discovery and development of an effective GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug.

KW - Growth hormone

KW - Growth hormone receptor

KW - Growth hormone receptor antagonist

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M3 - Review

C2 - 18058724

AN - SCOPUS:38449118318

SN - 0423-104X

VL - 58

SP - 322

EP - 329

JO - Endokrynologia Polska

JF - Endokrynologia Polska

IS - 4

ER -

Discovery and uses of pegvisomant: A growth hormone antagonist

Abstract

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