Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption

Mette G Sørensen; Kim Henriksen; Anita V Neutzsky-Wulff; Morten Hanefeld Dziegiel; Morten A Karsdal

doi:10.1359/jbmr.070613

Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption

Mette G Sørensen, Kim Henriksen, Anita V Neutzsky-Wulff, Morten Hanefeld Dziegiel, Morten A Karsdal

76 Citations (Scopus)

Abstract

Dissolution of the inorganic phase of bone by the osteoclasts mediated by V-ATPase and ClC-7 is a prerequisite for bone resorption. Inhibitors of osteoclastic V-ATPase or ClC-7 are novel approaches for inhibition of osteoclastic bone resorption. By testing natural compounds in acidification assays, diphyllin was identified. We characterized diphyllin with respect to the pharmacological effects on osteoclasts.

Original language	English
Journal	Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume	22
Issue number	10
Pages (from-to)	1640-8
Number of pages	9
ISSN	0884-0431
DOIs	https://doi.org/10.1359/jbmr.070613
Publication status	Published - Oct 2007

Keywords

Acids
Adrenal Medulla
Animals
Biological Transport
Bone Resorption
Cattle
Cell Survival
Cells, Cultured
Dioxolanes
Enzyme Inhibitors
Humans
Hydrogen-Ion Concentration
Lignans
Molecular Structure
Osteoclasts
Vacuolar Proton-Translocating ATPases

Access to Document

10.1359/jbmr.070613

Cite this

Sørensen, M. G., Henriksen, K., Neutzsky-Wulff, A. V., Dziegiel, M. H., & Karsdal, M. A. (2007). Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 22(10), 1640-8. https://doi.org/10.1359/jbmr.070613

Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption. / Sørensen, Mette G; Henriksen, Kim; Neutzsky-Wulff, Anita V et al.

In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 22, No. 10, 10.2007, p. 1640-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Sørensen, MG, Henriksen, K, Neutzsky-Wulff, AV, Dziegiel, MH & Karsdal, MA 2007, 'Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption', Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, vol. 22, no. 10, pp. 1640-8. https://doi.org/10.1359/jbmr.070613

Sørensen MG, Henriksen K, Neutzsky-Wulff AV, Dziegiel MH, Karsdal MA. Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2007 Oct;22(10):1640-8. doi: 10.1359/jbmr.070613

@article{75636f00fcfd486187a7b1e8c26e3770,

title = "Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption",

abstract = "Dissolution of the inorganic phase of bone by the osteoclasts mediated by V-ATPase and ClC-7 is a prerequisite for bone resorption. Inhibitors of osteoclastic V-ATPase or ClC-7 are novel approaches for inhibition of osteoclastic bone resorption. By testing natural compounds in acidification assays, diphyllin was identified. We characterized diphyllin with respect to the pharmacological effects on osteoclasts.",

keywords = "Acids, Adrenal Medulla, Animals, Biological Transport, Bone Resorption, Cattle, Cell Survival, Cells, Cultured, Dioxolanes, Enzyme Inhibitors, Humans, Hydrogen-Ion Concentration, Lignans, Molecular Structure, Osteoclasts, Vacuolar Proton-Translocating ATPases",

author = "S{\o}rensen, {Mette G} and Kim Henriksen and Neutzsky-Wulff, {Anita V} and Dziegiel, {Morten Hanefeld} and Karsdal, {Morten A}",

year = "2007",

month = oct,

doi = "10.1359/jbmr.070613",

language = "English",

volume = "22",

pages = "1640--8",

journal = "Journal of Bone and Mineral Research",

issn = "0884-0431",

publisher = "Wiley-Blackwell",

number = "10",

}

TY - JOUR

T1 - Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption

AU - Sørensen, Mette G

AU - Henriksen, Kim

AU - Neutzsky-Wulff, Anita V

AU - Dziegiel, Morten Hanefeld

AU - Karsdal, Morten A

PY - 2007/10

Y1 - 2007/10

N2 - Dissolution of the inorganic phase of bone by the osteoclasts mediated by V-ATPase and ClC-7 is a prerequisite for bone resorption. Inhibitors of osteoclastic V-ATPase or ClC-7 are novel approaches for inhibition of osteoclastic bone resorption. By testing natural compounds in acidification assays, diphyllin was identified. We characterized diphyllin with respect to the pharmacological effects on osteoclasts.

AB - Dissolution of the inorganic phase of bone by the osteoclasts mediated by V-ATPase and ClC-7 is a prerequisite for bone resorption. Inhibitors of osteoclastic V-ATPase or ClC-7 are novel approaches for inhibition of osteoclastic bone resorption. By testing natural compounds in acidification assays, diphyllin was identified. We characterized diphyllin with respect to the pharmacological effects on osteoclasts.

KW - Acids

KW - Adrenal Medulla

KW - Animals

KW - Biological Transport

KW - Bone Resorption

KW - Cattle

KW - Cell Survival

KW - Cells, Cultured

KW - Dioxolanes

KW - Enzyme Inhibitors

KW - Humans

KW - Hydrogen-Ion Concentration

KW - Lignans

KW - Molecular Structure

KW - Osteoclasts

KW - Vacuolar Proton-Translocating ATPases

U2 - 10.1359/jbmr.070613

DO - 10.1359/jbmr.070613

M3 - Journal article

C2 - 17576165

SN - 0884-0431

VL - 22

SP - 1640

EP - 1648

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

IS - 10

ER -

Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption

Abstract

Keywords

Access to Document

Fingerprint

Cite this